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Symbols MYO18B ; DKFZp434C2422; DKFZp779C1668; FLJ41942
External IDs OMIM607295 MGI1921626 HomoloGene53435 GeneCards: MYO18B Gene
RNA expression pattern
PBB GE MYO18B gnf1h07674 at tn.png
More reference expression data
Species Human Mouse
Entrez 84700 74376
Ensembl ENSG00000133454 ENSMUSG00000072720
UniProt Q8IUG5 E9PV66
RefSeq (mRNA) NM_032608 NM_028901
RefSeq (protein) NP_115997 NP_083177
Location (UCSC) Chr 22:
25.74 – 26.03 Mb
Chr 5:
112.69 – 112.9 Mb
PubMed search [1] [2]

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.[1][2][3]

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.[3]


  1. ^ Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad Sci U S A 99 (19): 12269–74. doi:10.1073/pnas.192445899. PMC 129434. PMID 12209013. 
  2. ^ Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID 12547197. 
  3. ^ a b "Entrez Gene: MYO18B myosin XVIIIB". 

Further reading[edit]

  • Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for metastatic phenotypes of lung cancer cells". Clin. Exp. Metastasis 20 (3): 189–93. doi:10.1023/A:1022978932215. PMID 12741677. 
  • Dunham I, Shimizu N, Roe BA et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Yanaihara N, Nishioka M, Kohno T et al. (2004). "Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer". Int. J. Cancer 112 (1): 150–4. doi:10.1002/ijc.20339. PMID 15305387. 
  • Inoue T, Kon T, Ajima R et al. (2006). "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway". Biochem. Biophys. Res. Commun. 342 (3): 829–34. doi:10.1016/j.bbrc.2006.02.025. PMID 16499872. 
  • Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Edakuni N, Ikuta K, Yano S et al. (2007). "Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice". Oncol. Res. 16 (5): 235–43. PMID 17294804.