MYO5B

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Myosin VB
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MYO5B ; KIAA1119
External IDs OMIM606540 MGI106598 HomoloGene49481 GeneCards: MYO5B Gene
RNA expression pattern
PBB GE MYO5B gnf1h05126 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4645 17919
Ensembl ENSG00000167306 ENSMUSG00000025885
UniProt Q9ULV0 P21271
RefSeq (mRNA) NM_001080467 NM_008661
RefSeq (protein) NP_001073936 NP_963894
Location (UCSC) Chr 18:
49.82 – 50.2 Mb
Chr 18:
74.44 – 74.77 Mb
PubMed search [1] [2]

Myosin-Vb is a protein that in humans is encoded by the MYO5B gene.[1][2][3]

Recent evidence suggests that Myosin VB is related to the creation of memories[4] by actin-dependent trafficking of AMPA receptor containing recycling endosomes in dendritic spines.[5]

Mutations of MYO5B cause microvillus inclusion disease[6] and have been associated with bipolar disorder.[7]

Interactions[edit]

MYO5B has been shown to interact with RAB11FIP2.[8]

References[edit]

  1. ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Sep 1996). "Mapping of unconventional myosins in mouse and human". Genomics 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266. 
  2. ^ Swiatecka-Urban A, Talebian L, Kanno E, Moreau-Marquis S, Coutermarsh B, Hansen K, Karlson KH, Barnaby R, Cheney RE, Langford GM, Fukuda M, Stanton BA (Aug 2007). "Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells". The Journal of Biological Chemistry 282 (32): 23725–36. doi:10.1074/jbc.M608531200. PMID 17462998. 
  3. ^ "Entrez Gene: MYO5B myosin VB". 
  4. ^ "DukeHealth.org: Scientists Identify Machinery that Helps Make Memories". Retrieved 2014-03-25. 
  5. ^ Wang Z, Edwards JG, Riley N, Provance DW, Karcher R, Li XD, Davison IG, Ikebe M, Mercer JA, Kauer JA, Ehlers MD (Oct 2008). "Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity". Cell 135 (3): 535–48. doi:10.1016/j.cell.2008.09.057. PMC 2585749. PMID 18984164. 
  6. ^ Müller T, Hess MW, Schiefermeier N, Pfaller K, Ebner HL, Heinz-Erian P, Ponstingl H, Partsch J, Röllinghoff B, Köhler H, Berger T, Lenhartz H, Schlenck B, Houwen RJ, Taylor CJ, Zoller H, Lechner S, Goulet O, Utermann G, Ruemmele FM, Huber LA, Janecke AR (Oct 2008). "MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity". Nature Genetics 40 (10): 1163–5. doi:10.1038/ng.225. PMID 18724368. 
  7. ^ Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM (Jun 2008). "Whole-genome association study of bipolar disorder". Molecular Psychiatry 13 (6): 558–69. doi:10.1038/sj.mp.4002151. PMID 18317468. 
  8. ^ Hales CM, Vaerman JP, Goldenring JR (Dec 2002). "Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling". The Journal of Biological Chemistry 277 (52): 50415–21. doi:10.1074/jbc.M209270200. PMID 12393859. 

Further reading[edit]

External links[edit]