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Protein MYO6 PDB 2bkh.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesMYO6, DFNA22, DFNB37, myosin VI, Myo6-008, Myo6-007
External IDsMGI: 104785 HomoloGene: 56417 GeneCards: MYO6
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for MYO6
Genomic location for MYO6
Band6q14.1Start75,749,192 bp[1]
End75,919,537 bp[1]
RNA expression pattern
PBB GE MYO6 210480 s at fs.png

PBB GE MYO6 203216 s at fs.png

PBB GE MYO6 203215 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 6: 75.75 – 75.92 MbChr 9: 80.17 – 80.31 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Myosin VI, also known as MYO6, is a protein. It has been found in humans, mice, fruit flies (Drosophila melanogaster), and nematodes (Caenorhabditis elegans).


Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins.[supplied by OMIM][5]


MYO6 has been shown to interact with GIPC1[6][7] and DAB2.[8][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196586 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033577 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: MYO6 myosin VI".
  6. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  7. ^ Sennacherib L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Molecular Biology of the Cell. 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860.
  8. ^ Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127.
  9. ^ Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.

Further reading[edit]