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Myosin VI
Protein MYO6 PDB 2bkh.png
PDB rendering based on 2bkh.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MYO6 ; DFNA22; DFNB37
External IDs OMIM600970 MGI104785 HomoloGene56417 GeneCards: MYO6 Gene
RNA expression pattern
PBB GE MYO6 203216 s at tn.png
PBB GE MYO6 203215 s at tn.png
PBB GE MYO6 210480 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4646 17920
Ensembl ENSG00000196586 ENSMUSG00000033577
UniProt Q9UM54 E9PVU0
RefSeq (mRNA) NM_001300899 NM_001039546
RefSeq (protein) NP_001287828 NP_001034635
Location (UCSC) Chr 6:
75.75 – 75.92 Mb
Chr 9:
80.17 – 80.31 Mb
PubMed search [1] [2]

Myosin VI, also known as MYO6, is a protein. It has been found in humans, mice, fruit flies (Drosophila melanogaster), and nematodes (Caenorhabditis elegans).


Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins.[supplied by OMIM][1]


MYO6 has been shown to interact with GIPC1[2][3] and DAB2.[4][5]


  1. ^ "Entrez Gene: MYO6 myosin VI". 
  2. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  3. ^ Aschenbrenner L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Molecular Biology of the Cell 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860. 
  4. ^ Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127. 
  5. ^ Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161. 

Further reading[edit]