MYST1

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KAT8
Protein MYST1 PDB 1wgs.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KAT8, MOF, MYST1, ZC2HC8, hMOF, lysine acetyltransferase 8
External IDs MGI: 1915023 HomoloGene: 41676 GeneCards: KAT8
RNA expression pattern
PBB GE MYST1 221820 s at fs.png

PBB GE MYST1 214885 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032188
NM_182958

NM_026370

RefSeq (protein)

NP_115564
NP_892003

NP_080646.1
NP_080646

Location (UCSC) Chr 16: 31.12 – 31.13 Mb Chr 7: 127.91 – 127.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Probable histone acetyltransferase MYST1 is an enzyme that in humans is encoded by the MYST1 gene.[3][4]

Function[edit]

The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin.[4]

Interactions[edit]

MYST1 has been shown to interact with MORF4L1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Neal KC, Pannuti A, Smith ER, Lucchesi JC (Jan 2000). "A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF". Biochimica et Biophysica Acta. 1490 (1-2): 170–4. doi:10.1016/s0167-4781(99)00211-0. PMID 10786633. 
  4. ^ a b "Entrez Gene: MYST1 MYST histone acetyltransferase 1". 
  5. ^ Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM (Dec 2002). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation". The Journal of Biological Chemistry. 277 (52): 50860–6. doi:10.1074/jbc.M203839200. PMID 12397079. 

Further reading[edit]