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Myelin transcription factor 1
Symbols MYT1 ; C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2HC4A
External IDs OMIM600379 MGI1100535 HomoloGene3332 GeneCards: MYT1 Gene
RNA expression pattern
PBB GE MYT1 210341 at tn.png
PBB GE MYT1 215822 x at tn.png
More reference expression data
Species Human Mouse
Entrez 4661 17932
Ensembl ENSG00000196132 ENSMUSG00000010505
UniProt Q01538 Q8CFC2
RefSeq (mRNA) NM_004535 NM_001171615
RefSeq (protein) NP_004526 NP_001165086
Location (UCSC) Chr 20:
64.15 – 64.24 Mb
Chr 2:
181.76 – 181.83 Mb
PubMed search [1] [2]

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.[1][2][3]

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.[3]


MYT1 has been shown to interact with PIN1.[4]


  1. ^ Kim JG, Hudson LD (Dec 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Mol Cell Biol 12 (12): 5632–9. PMC 360502. PMID 1280325. 
  2. ^ Booher RN, Holman PS, Fattaey A (Oct 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J Biol Chem 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380. 
  3. ^ a b "Entrez Gene: MYT1 myelin transcription factor 1". 
  4. ^ Wells, N J; Watanabe N; Tokusumi T; Jiang W; Verdecia M A; Hunter T (Oct 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". J. Cell. Sci. (ENGLAND) 112 (19): 3361–71. ISSN 0021-9533. PMID 10504341. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.