MYT1

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MYT1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MYT1, C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2HC4A, ZC2H2C1, myelin transcription factor 1
External IDs MGI: 1100535 HomoloGene: 3332 GeneCards: 4661
RNA expression pattern
PBB GE MYT1 210341 at tn.png

PBB GE MYT1 215822 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004535

NM_001171615
NM_001171616
NM_001171680
NM_008665

RefSeq (protein)

NP_004526.1

NP_001165086.1
NP_001165087.1
NP_032691.2

Location (UCSC) Chr 20: 64.15 – 64.24 Mb Chr 2: 181.76 – 181.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.[3][4][5]

Function[edit]

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.[5]

Interactions[edit]

MYT1 has been shown to interact with PIN1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kim JG, Hudson LD (Dec 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology. 12 (12): 5632–9. doi:10.1128/mcb.12.12.5632. PMC 360502free to read. PMID 1280325. 
  4. ^ Booher RN, Holman PS, Fattaey A (Aug 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380. 
  5. ^ a b "Entrez Gene: MYT1 myelin transcription factor 1". 
  6. ^ Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (Oct 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science. 112 (19): 3361–71. PMID 10504341. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.