|Chemical and physical data|
|Formula||(C2H6OSi)n · (SiO2)m|
|(what is this?)|
Simethicone is an orally administered anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas — mainly swallowed air, with small amounts of hydrogen and methane— in the stomach or intestines. In addition to that, it is administered orally after intoxication with detergents. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel.
Mechanism of action
Simethicone is an anti-foaming agent that decreases the surface tension of gas bubbles, causing them to combine into larger bubbles in the stomach that can be passed more easily. Simethicone does not reduce or prevent the formation of gas in the digestive tract; rather, it increases the rate at which it exits the body. Simethicone can relieve pain caused by gas in the intestines by decreasing foaming, which then allows for easier passing of flatulence.
Simethicone is not absorbed by the body into the bloodstream and is therefore considered relatively safe. National Institutes of Health (NIH) reports there are usually no side effects when simethicone is taken as directed. Although simethicone has also been promoted as a treatment for colic in babies, randomised controlled trials have not demonstrated efficacy for this use; despite traditional views on the subject, colic does not appear to be caused by gas.
Simethicone is generally available over the counter under many brand names in varying dosage sizes and combinations with other drugs, including:
- Aero-Red (Spain)
- Air-X (Thailand)
- Anaflat (Teva)
- Antacil (Thailand)
- Antiflat (Austria)
- Baby's Own Infant Drops
- Bearse (Korea)
- Bloateze (Phoenix Labs - Ireland)
- De-Gas (Jordan,Thailand, Australia)
- Di-gel (di-gel Health Products, LLC - USA)
- Disflatyl (Egypt, Thailand, Malaysia)
- Dulcogas (Turkey, Australia, Denmark)
- Espumisan (Bulgaria, Hungary, Romania, Poland, Ukraine, Czech Republic, Slovakia, Croatia, Russia, Macedonia)
- Flapex (Chile)
- Flatin (HU)
- Factor AG 200 (Argentina)
- Gascon (Taiwan)
- Gas Relief
- Gasvan (Serbia)
- Gas X (Thailand)
- Gazim X (Israel)
- Gaszym (Thailand)
- Imodium Multi-Symptom Relief (formerly Imodium Advanced)
- Kupla Stop (Finland)
- Lefax (Germany)
- Little Tummys
- Luftal (Brazil and Mexico)
- Maalox Anti-Gas
- Maalox Max
- Meteoxane (France)
- Metsil (Turkey)
- Minicol (Pakistan)
- Minifom (Norway, Sweden)
- My Baby Gas Relief Drops
- Mylanta Gas
- Mylanta Gas Relief
- Mylicon Drops
- Mylicongas (Italy)
- Rantac-MPS(UNIQUE PHARMA, India)
- Refalgin (IT)
- Rennie Deflatine
- SAB Simplex
- Salinal (Lebanon, Bahrain)
- Silan (Uruguay)
- Siloxogene (India)
- Simeco (Philippines)
- Simicol (Israel)
- Telament colic drops (South Africa)
- Triaerom (Peru)
- WindEze (UK)
- "Gas in the Digestive Tract - Johns Hopkins Medicine Health Library".
- "Intestinal Gas - Gastrointestinal Society".
- Norton, William (2005-01-09). "Controlling Intestinal Gas". Retrieved 2007-07-31.
- PubMed Health, produced by National Center for Biotechnology, a division of the National Library of Medicine at the National Institutes of Health; see http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000747/
- "Infant Gas Drops Review".
- University of Michigan clinical trial for simethicone used for colic
- "Baby Colic & Infantile colic. Baby Colic information. Patient - Patient".
- Product information (in German)
- Product information (in German)
- from Micromedex Dug Information. Retrieved 2013-01-13.
- "Jackson Gastroenterology - Patient Education - Simethicone". Retrieved Nov 11, 2013.
- "Medline Plus - Simethicone". Archived from the original on February 19, 2007. Retrieved Nov 11, 2013.