From Wikipedia, the free encyclopedia
  (Redirected from Maalox Anti-Gas)
Jump to: navigation, search
Simethicone structure.svg
Clinical data
AHFS/ Monograph
  • C
Routes of
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability None
Protein binding 0%
Metabolism Not metabolized
Biological half-life N/A
Excretion feces
CAS Number
PubChem CID
  • none
ECHA InfoCard 100.107.016
Chemical and physical data
Formula (C2H6OSi)n · (SiO2)m
Molar mass variable
 NYesY (what is this?)  (verify)

Simethicone is an orally administered anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas — mainly swallowed air, with small amounts of hydrogen and methane[1][2]— in the stomach or intestines. In addition to that, it is administered orally after intoxication with detergents. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel.

Mechanism of action[edit]

Simethicone is an anti-foaming agent that decreases the surface tension of gas bubbles, causing them to combine into larger bubbles in the stomach that can be passed more easily. Simethicone does not reduce or prevent the formation of gas in the digestive tract; rather, it increases the rate at which it exits the body.[3] Simethicone can relieve pain caused by gas in the intestines by decreasing foaming, which then allows for easier passing of flatulence.

Medical uses[edit]

Simethicone is not absorbed by the body into the bloodstream and is therefore considered relatively safe. National Institutes of Health (NIH)[4] reports there are usually no side effects when simethicone is taken as directed. Although simethicone has also been promoted as a treatment for colic in babies, randomised controlled trials have not demonstrated efficacy for this use;[5] despite traditional views on the subject, colic does not appear to be caused by gas.[6][7]


Simethicone is generally available over the counter under many brand names in varying dosage sizes and combinations with other drugs, including:

  • Aero-Red (Spain)
  • Air-X (Thailand)
  • Anaflat (Teva)
  • Antacil (Thailand)
  • Antiflat[8][9] (Austria)
  • Baby's Own Infant Drops
  • Bearse (Korea)
  • Bloateze (Phoenix Labs - Ireland)
  • Deflatine
  • De-Gas (Jordan,Thailand, Australia)
  • Di-gel (di-gel Health Products, LLC - USA)
  • Disflatyl (Egypt, Thailand, Malaysia)
  • Dulcogas (Turkey, Australia, Denmark)
  • Espumisan (Bulgaria, Hungary, Romania, Poland, Ukraine, Czech Republic, Slovakia, Croatia, Russia, Macedonia)
  • Flapex (Chile)
  • Flatin (HU)
  • Flatulex
  • Factor AG 200 (Argentina)
  • GasAid
  • Gascon (Taiwan)
  • Gas-Med
  • Gas Relief
  • Gasvan (Serbia)
  • Gas-X
  • Gas X (Thailand)
  • Gazim X (Israel)
  • Gaszym (Thailand)
  • Genasyme
  • Imodium Multi-Symptom Relief (formerly Imodium Advanced)
  • Imogas
  • Imonogas
  • Infacol
  • Infacon
  • Kremil-S
  • Kupla Stop (Finland)
  • Lefax (Germany)
  • Little Tummys
  • Luftal (Brazil and Mexico)
  • Maalox Anti-Gas
  • Maalox Max
  • Mag77
  • Meteoxane (France)
  • Metsil (Turkey)
  • Minicol (Pakistan)
  • Minifom (Norway, Sweden)
  • My Baby Gas Relief Drops
  • Mylanta Gas
  • Mylanta Gas Relief
  • Mylicon Drops
  • Mylicongas (Italy)
  • Ovol
  • Phazyme
  • Rantac-MPS(UNIQUE PHARMA, India)
  • Refalgin (IT)
  • Rennie Deflatine
  • Rolaids
  • SAB Simplex
  • Salinal (Lebanon, Bahrain)
  • Silan (Uruguay)
  • Siloxogene (India)
  • Simeco (Philippines)
  • Simicol (Israel)
  • Telament colic drops (South Africa)
  • Triaerom (Peru)
  • WindEze (UK)

Side effects[edit]

The most common adverse effects of simethicone are gastrointestinal symptoms, including mild diarrhea, nausea, regurgitation, and vomiting.[10]


  1. ^ "Gas in the Digestive Tract - Johns Hopkins Medicine Health Library". 
  2. ^ "Intestinal Gas - Gastrointestinal Society". 
  3. ^ Norton, William (2005-01-09). "Controlling Intestinal Gas". Retrieved 2007-07-31. 
  4. ^ PubMed Health, produced by National Center for Biotechnology, a division of the National Library of Medicine at the National Institutes of Health; see
  5. ^ "Infant Gas Drops Review". 
  6. ^ University of Michigan clinical trial for simethicone used for colic
  7. ^ "Baby Colic & Infantile colic. Baby Colic information. Patient - Patient". 
  8. ^ Product information (in German)
  9. ^ Product information (in German)
  10. ^ from Micromedex Dug Information. Retrieved 2013-01-13.

External links[edit]