The family claims noble descent from the legitimate grandchildren of Lakandula, the last "王" or King of Tondo "東都" (Dongdu). It is the only known branch of the Seludong's royal family to have survived the Majapahit Empire's invasion, the Sultanate of Brunei's pogrom against native royals, Chinese warlord Limahong's massacres, and the fallout from the Tondo Conspiracy. The family survived due to Martin de Goiti's giving of his Mestiza (Half Aztec and Half-Spanish) daughter in marriage to Batang Dula. As time went on, they incorporated the descendants from the two other royal houses: the house of Rajah Matanda (ऋअज ंअतन्द) and the house of Tariq Suleiman (سليمان).
The following are people possessing the Macapagal surname:
- Don Juan Macapagal (d. 1683) - former prince of Tondo and first documented bearer of the surname. Great-grandson of Lakandula.
- Lazaro Macapagal (c. 1860s) - officer of the Philippine Revolution. Commanding officer ordered to execute Philippine national hero Andrés Bonifacio.
- Diosdado Macapagal (1910-1997) - 9th President of the Philippines (1961-1965)
- Gloria Macapagal-Arroyo (born 1947) - daughter of above and 14th President of the Philippines
- Maan Macapagal - ABS-CBN television news reporter
- Mark Macapagal (born 1979) - Filipino professional basketball player
- Cesar S. Macapagal - son of Emiterio Macapagal
- Mona Lisa S. Macapagal - daughter of Cesar S. Macapagal
- Julius Vincent Macapagal - nephew of Gloria Macapagal-Arroyo
- Atty. Ciriaco A. Macapagal - Attorney At Law
- Engelbert R. Macapagal - Network Planner KFC Phil.
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