Mack may refer to:
- Mack (given name)
- Mack (surname)
- Reinhold Mack, German record producer and sound engineer, often credited as simply "Mack"
- Richard Machowicz (1965–2017), host of FutureWeapons and Deadliest Warrior, known as "Mack"
- Mack, Colorado, an unincorporated town
- Mack, Louisiana, an unincorporated community
- Mack, Minnesota, an unincorporated town
- Mack, Ohio, a census-designated place
- Mack Trucks, an American truck maker
- Mack Group, an American corporation providing contract manufacturing
- Mack Brewery, a Norwegian brewery
- Mack Rides, a German ride manufacturer
- Mack Air, a Botswana air charter line
- Mack (publishing), an art and photography publishing house based in London
- USS Mack (DE-358), a destroyer escort which served in World War II
- Mack (naval architecture), in naval architecture, a structure combining a ship's radar masts and funnels
- The Mack, a 1973 blaxploitation film
- Mack Park, original home field of the Detroit Stars Negro National League baseball franchise
- Mack is the Character of Disney Pixar Cars.