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A Macro key is a key that was featured on various early PC keyboards, and has been removed from most keyboards since. It is typically found on the lower rows of the keyboard, either to the left of the Z key or to the right of the right Ctrl. While most keyboard layouts treat it as a backslash, it has a different scan code, so keyboard layouts or programs use the scan code directly, or they can choose to handle it differently.
On many new, top-of-the-line computer mice, there are built-in macro keys. These mice often come with a software specifically designed to fit the needs of that mouse.
These keys are sometimes used by gamers as rapid-fire buttons, for an edge over the opponent.
Simply put the gaming macro key is a recording of a series of key sequences. A key sequence is a series of keyboard keystrokes, mouse actions, or menu actions that is bound to a command. The macro key can also be used to conveniently launch a program.