Magnesium transporter E
| MgtE | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||
| Symbol | MgtE | ||||||||
| Pfam | PF01769 | ||||||||
| InterPro | IPR006667 | ||||||||
| TCDB | 1.A.26 | ||||||||
| OPM superfamily | 201 | ||||||||
| OPM protein | 2yvx | ||||||||
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Magnesium transporters E (MgtE) are a family of transmembrane eubacterial MgtE magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding.
Human transporters from this family are SLC41A1, SLC41A2 and SLC41A3.
References
- ^ Hattori, M.; Iwase, N.; Furuya, N.; Tanaka, Y.; Tsukazaki, T.; Ishitani, R.; Maguire, M. E.; Ito, K.; Maturana, A.; Nureki, O. (2009). "Mg2+-dependent gating of bacterial MgtE channel underlies Mg2+ homeostasis". The EMBO Journal. 28 (22): 3602–3612. doi:10.1038/emboj.2009.288. PMC 2782099. PMID 19798051.