Magnolysin

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Magnolysin
Identifiers
EC number 3.4.24.62
CAS number 162875-09-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Magnolysin (EC 3.4.24.62, bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin, pro-oxytocin/neurophysin convertase, prooxyphysin proteinase, pro-oxytocin convertase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg-Ala-Val-.

This endopeptidase is present in bovine pituitary neurosecretory granules.

References[edit]

  1. ^ Clamagirand, C.; Creminon, C.; Fahy, C.; Boussetta, H.; Cohen, P. (1987). "Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytosin/neurophysin peptides at the basic amino acid doublet". Biochemistry. 26: 6018–6023. PMID 2825769. doi:10.1021/bi00393a011. 
  2. ^ Créminon, C.; Rholam, M.; Boussetta, H.; Marrakchi, N.; Cohen, P. (1988). "Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme". J. Chromatogt. 440: 439–448. PMID 3042797. doi:10.1016/s0021-9673(00)94547-3. 
  3. ^ Brakch, N.; Boussetta, H.; Rholam, M.; Cohen, P. (1989). "Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model". J. Biol. Chem. 264: 15912–15916. PMID 2674120. 
  4. ^ Plevrakis, I; Créminon, C.; Clamagirand, C.; Brakch, N.; Rholam, M.; Cohen, P. (1989). "Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor". Biochemistry. 28: 2705–2710. PMID 2659078. doi:10.1021/bi00432a051. 
  5. ^ Guillou, M.D.; Camier, M.; Clamagirand, C. (1994). "Evidence for the presence of pro-oxytocin/neurophysin converting enzyme in the human ovary". J. Endocrinol. 142: 345–352. PMID 7931007. doi:10.1677/joe.0.1420345. 

External links[edit]