From Wikipedia, the free encyclopedia
Jump to: navigation, search
EC number
CAS number 162875-09-4
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Magnolysin (EC, bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin, pro-oxytocin/neurophysin convertase, prooxyphysin proteinase, pro-oxytocin convertase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg-Ala-Val-.

This endopeptidase is present in bovine pituitary neurosecretory granules.


  1. ^ Clamagirand, C.; Creminon, C.; Fahy, C.; Boussetta, H.; Cohen, P. (1987). "Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytosin/neurophysin peptides at the basic amino acid doublet". Biochemistry. 26: 6018–6023. PMID 2825769. doi:10.1021/bi00393a011. 
  2. ^ Créminon, C.; Rholam, M.; Boussetta, H.; Marrakchi, N.; Cohen, P. (1988). "Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme". J. Chromatogt. 440: 439–448. PMID 3042797. doi:10.1016/s0021-9673(00)94547-3. 
  3. ^ Brakch, N.; Boussetta, H.; Rholam, M.; Cohen, P. (1989). "Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model". J. Biol. Chem. 264: 15912–15916. PMID 2674120. 
  4. ^ Plevrakis, I; Créminon, C.; Clamagirand, C.; Brakch, N.; Rholam, M.; Cohen, P. (1989). "Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor". Biochemistry. 28: 2705–2710. PMID 2659078. doi:10.1021/bi00432a051. 
  5. ^ Guillou, M.D.; Camier, M.; Clamagirand, C. (1994). "Evidence for the presence of pro-oxytocin/neurophysin converting enzyme in the human ovary". J. Endocrinol. 142: 345–352. PMID 7931007. doi:10.1677/joe.0.1420345. 

External links[edit]