In its upper course the river runs as an entrenched torrent through the Andes mountains. Here, it receives three major tributaries: El Volcán River, Yeso River and Colorado River. After leaving the Andes, the Maipo flows through the valley that bears its name. It is the best known wine-producing region in Chile. The Maipo River travels 250 km before emptying into the Pacific Ocean near the locality of Llolleo, south of the port of San Antonio.
^ abCai, Ximing; Claudia Ringler; Mark W. Rosegrant (2006). Modeling Water Resources Management at the Basin Level: Methodology and Application to the Maipo River Basin. Washington DC: International Food Policy Research Institute. ISBN978-0-89629-152-2.