Major histocompatibility complex, class I-related

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MR1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MR1, HLALS, Major histocompatibility complex, class I-related
External IDs MGI: 1195463 HomoloGene: 123981 GeneCards: MR1
RNA expression pattern
PBB GE MR1 207566 at fs.png

PBB GE MR1 210223 s at fs.png

PBB GE MR1 207565 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001194999
NM_001195000
NM_001195035
NM_001310213
NM_001531

NM_008209

RefSeq (protein)

NP_001181928
NP_001181929
NP_001181964
NP_001297142
NP_001522

NP_032235.1
NP_032235

Location (UCSC) Chr 1: 181.03 – 181.06 Mb Chr 1: 155.13 – 155.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Major histocompatibility complex class I-related gene protein is a protein that in humans is encoded by the MR1 gene.[3][4][5] The MR1 protein is able to bind to molecules derived from bacterial riboflavin biosynthesis, and then present it to mucosal associated invariant T cells for activation.[6][7]


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hashimoto K, Hirai M, Kurosawa Y (Aug 1995). "A gene outside the human MHC related to classical HLA class I genes". Science. 269 (5224): 693–5. doi:10.1126/science.7624800. PMID 7624800. 
  4. ^ Yamaguchi H, Kurosawa Y, Hashimoto K (Nov 1998). "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog". Biochem Biophys Res Commun. 250 (3): 558–64. doi:10.1006/bbrc.1998.9353. PMID 9784382. 
  5. ^ "Entrez Gene: MR1 major histocompatibility complex, class I-related". 
  6. ^ Corbett, Alexandra J.; Eckle, Sidonia B. G.; Birkinshaw, Richard W.; Liu, Ligong; Patel, Onisha; Mahony, Jennifer; Chen, Zhenjun; Reantragoon, Rangsima; Meehan, Bronwyn. "T-cell activation by transitory neo-antigens derived from distinct microbial pathways". Nature. 509 (7500): 361–365. doi:10.1038/nature13160. 
  7. ^ Kjer-Nielsen, Lars; Patel, Onisha; Corbett, Alexandra J.; Nours, Jérôme Le; Meehan, Bronwyn; Liu, Ligong; Bhati, Mugdha; Chen, Zhenjun; Kostenko, Lyudmila. "MR1 presents microbial vitamin B metabolites to MAIT cells". Nature. doi:10.1038/nature11605. 

Further reading[edit]