"Make It Rain" is the first single released from Fat Joe's seventh album Me, Myself & I. It features American rapper Lil Wayne, who only sings the chorus (but contributes a verse on the remix), and was produced by Scott Storch. It peaked at #13 on the Billboard Hot 100. It was nominated for a Grammy at the 2008 Grammy Awards. The Exclusive Def Jam Version, which does not feature Lil Wayne and instead has a hook by Fat Joe, is featured in the game Def Jam: Icon and is Fat Joe's fighting song.
A remix was recorded in December 2006 and released as a single in 2007. It features American singer R. Kelly and American rappers T.I., Lil Wayne, Birdman, Rick Ross and Ace Mac, as well as uncredited vocals by DJ Khaled, and was produced by Scott Storch. There is also an official video for the remix. Sean Kingston has made his own version. There is also a shortened remix featuring only R. Kelly as well as a verse from Lil Wayne. Its featured on Fat Joe's mixtape titled The Crack Era.