Malate dehydrogenase (decarboxylating)

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NAD-malic enzyme
malic enzyme tetramer, Human
EC no.
CAS no.9028-46-0
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Malate dehydrogenase (decarboxylating) (EC or NAD-malic enzyme (NAD-ME) is an enzyme that catalyzes the chemical reaction

(S)-malate + NAD+ pyruvate + CO2 + NADH

Thus, the two substrates of this enzyme are (S)-malate and NAD+, whereas its three products are pyruvate, CO2, and NADH. Malate is oxidized to pyruvate and CO2, and NAD+ is reduced to NADH.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD+ oxidoreductase (decarboxylating). This enzyme participates in pyruvate metabolism and carbon fixation. NAD-malic enzyme is one of three decarboxylation enzymes used in the inorganic carbon concentrating mechanisms of C4 and CAM plants. The others are NADP-malic enzyme and PEP carboxykinase.[1][2]


  1. ^ Kanai R, Edwards, GE (1999). "3. The Biochemistry of C4 Photosynthesis". In Sage RF, Monson RK (eds.). C4 Plant Biology. pp. 43–87. ISBN 0126144400.
  2. ^ Christopher JT, Holtum JA (1996). "Patterns of carbon partitioning in leaves of Crassulacean acid metabolism species during deacidification". Plant Physiol. 112 (1): 393–399. doi:10.1104/pp.112.1.393. PMC 157961. PMID 12226397.
  • Saz HJ, Hubbard JA (1957). "The oxidative decarboxylation of malate by Ascaris lumbricoides". J. Biol. Chem. 225 (2): 921–933. PMID 13416294.