Malate dehydrogenase (quinone)

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malate dehydrogenase (quinone)
EC number1.1.5.4
CAS number71822-24-7
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a malate dehydrogenase (quinone) (EC, formerly malate dehydrogenase (acceptor) (EC, is an enzyme that catalyzes the chemical reaction

(S)-malate + a quinone oxaloacetate + reduced quinone

Thus, the two substrates of this enzyme are (S)-malate and a quinone, whereas its two products are oxaloacetate and reduced quinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a quinone as acceptor. The systematic name of this enzyme class is (S)-malate:quinone oxidoreductase. Other names in common use include FAD-dependent malate-vitamin K reductase, malate-vitamin K reductase, and (S)-malate:(quinone) oxidoreductase. This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.


  • Imai D; Brodie AF (1973). "A phospholipid-requiring enzyme, malate-vitamin K reductase". J. Biol. Chem. 248: 7487–7494.
  • Imai T (1978). "FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties". Biochim. Biophys. Acta. 523 (1): 37–46. doi:10.1016/0005-2744(78)90006-2. PMID 629992.
  • Prasada Reddy TL, Suryanarayana Murthy P, Venkitasubramanian TA (1975). "Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria". Biochim. Biophys. Acta. 376 (2): 210–8. doi:10.1016/0005-2728(75)90012-2. PMID 234747.