Maleylacetoacetate isomerase

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maleylacetoacetate isomerase
EC number
CAS number 9023-75-0
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a maleylacetoacetate isomerase (EC is an enzyme that catalyzes the chemical reaction

4-maleylacetoacetate 4-fumarylacetoacetate

Hence, this enzyme has one substrate, 4-maleylacetoacetate, and one product, 4-fumarylacetoacetate.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 4-maleylacetoacetate cis-trans-isomerase. Other names in common use include maleylacetoacetic isomerase, maleylacetone isomerase, and maleylacetone cis-trans-isomerase. This enzyme participates in tyrosine metabolism and styrene degradation.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1FW1, 2CZ2, and 2CZ3.


  • EDWARDS SW, KNOX WE (1956). "Homogentisate metabolism: the isomerization of maleylacetoacetate by an enzyme which requires glutathione". J. Biol. Chem. 220 (1): 79–91. PMID 13319328. 
  • Lack L (1961). "Enzymic cis-trans isomerization of maleylpyruvic acid". J. Biol. Chem. 236: 2835–2840. PMID 14461395. 
  • Seltzer S (1973). "Purification and properties of maleylacetone cis-trans isomerase from vibrio 01". J. Biol. Chem. 248 (1): 215–22. PMID 4692831.