In histopathology, a Mallory body, Mallory-Denk body, and Mallory's hyaline, is an inclusion found in the cytoplasm of liver cells. Mallory bodies are damaged intermediate filaments within the hepatocytes.
They are a recognized feature of Wilson's disease (25%), primary biliary cirrhosis (24%), non-alcoholic cirrhosis (24%), hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions. However, it has also been reported in certain other unrelated conditions.
Mallory bodies are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate cytokeratin 8/18 filament proteins that have been ubiquinated, or bound by other proteins such as heat shock proteins, or p62/Sequestosome 1.
It is named for the American pathologist Frank Burr Mallory, who first described the structures in 1911. They were renamed as Mallory-Denk bodies in 2007 to honor the contribution of Austrian pathologist Helmut Denk for the molecular analysis of the pathogenesis of MDBs.
- "Cell Injury".
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- Jensen, K; Gluud, C (Oct 1994). "The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey)". Hepatology. 20 (4 Pt 1): 1061–77. doi:10.1002/hep.1840200440. PMID 7927209.
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- Stumptner, Conny; Fuchsbichler, Andrea; Zatloukal, Kurt; Denk, Helmut (2007). "In vitro production of Mallory bodies and intracellular hyaline bodies: The central role of sequestosome 1 / p62". Hepatology. 46 (3): 851–860. doi:10.1002/hep.21744. PMID 17685470.