Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAMgene.
Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against maltose, while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers. In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches. Maltase-Glucoamylase deficiency is rare and is similar in sequence to the enzyme sucrase-isomaltase. Maltase-Glucoamylase serves as an alternative pathway for starch digestion. Symptoms of this deficiency is similar to Congenital-Sucrase Isomaltase Deficiency (CSID), where the individual suffering from this cannot break down sugars such as sucrose and maltose. Diagnosis of Maltase-Glucoamylase deficiency requires to monitor the reduced glucoamylase activity via small bowel histology.
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