Maltase-glucoamylase

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"MGAM" redirects here. For other uses, see MGAM (disambiguation).
MGAM
PDB 2qly EBI.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases MGAM, MG, MGA, Maltase-glucoamylase
External IDs MGI: 1203495 HomoloGene: 130099 GeneCards: MGAM
Targeted by Drug
miglitol[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004668

NM_001171003

RefSeq (protein)

NP_004659.2

n/a

Location (UCSC) Chr 7: 141.91 – 142.11 Mb Chr 6: 40.63 – 40.77 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAM gene.[4][5]

Maltase-glucoamylase is alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against maltose, while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers.[6] In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches.

See also[edit]

References[edit]

  1. ^ "Drugs that physically interact with Maltase-glucoamylase, intestinal view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: maltase-glucoamylase (alpha-glucosidase)". 
  5. ^ Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A, Sterchi E (January 1998). "Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase". J. Biol. Chem. 273 (5): 3076–81. doi:10.1074/jbc.273.5.3076. PMID 9446624. 
  6. ^ Quezada-Calvillo R, Sim L, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Sterchi EE, Robayo-Torres CC, Rose DR, Nichols BL (2008). "Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit". J. Nutr. 138 (4): 685–92. PMID 18356321. 

Further reading[edit]