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PDB 2qly EBI.png
Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesMGAM, MG, MGA, Maltase-glucoamylase
External IDsOMIM: 154360 MGI: 1203495 HomoloGene: 130099 GeneCards: MGAM
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for MGAM
Genomic location for MGAM
Band7q34Start141,907,813 bp[1]
End142,106,747 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 7: 141.91 – 142.11 MbChr 6: 40.63 – 40.77 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAM gene.[5][6]

Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against maltose, while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers.[7] In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches. Maltase-Glucoamylase deficiency is rare and is similar in sequence to the enzyme sucrase-isomaltase. Maltase-Glucoamylase serves as an alternative pathway for starch digestion. Symptoms of this deficiency is similar to Congenital-Sucrase Isomaltase Deficiency (CSID), where the individual suffering from this cannot break down sugars such as sucrose and maltose. Diagnosis of Maltase-Glucoamylase deficiency requires to monitor the reduced glucoamylase activity via small bowel histology.

See also[edit]


  1. ^ a b c ENSG00000282607 GRCh38: Ensembl release 89: ENSG00000257335, ENSG00000282607 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068587 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: maltase-glucoamylase (alpha-glucosidase)".
  6. ^ Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A, Sterchi E (January 1998). "Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase". J. Biol. Chem. 273 (5): 3076–81. doi:10.1074/jbc.273.5.3076. PMID 9446624.
  7. ^ Quezada-Calvillo R, Sim L, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Sterchi EE, Robayo-Torres CC, Rose DR, Nichols BL (2008). "Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit". J. Nutr. 138 (4): 685–92. PMID 18356321.

Further reading[edit]

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Maltase-glucoamylase, intestinal