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Manabe Akifusa(間部 詮房?, June 18, 1666 – August 7, 1720) was a feudal lord in Japan, and Ienobu's attendant.
Manabe was born in Edo, Japan, the son of a Noh actor and became a servant to the sixth Edo shogun, Tokugawa Ienobu. Manabe held the titles of Sobayonin and Daimyo of Takasaki and dominated Ienobu's cabinet. Even after Ienobu's death, he remained a powerful figure during the short reign of the seventh shogun, Tokugawa Ietsugu. After the death of Ietsugu, Manabe resigned from public office and was moved to Murakami, Echigo-koku by the eighth shogun, Tokugawa Yoshimune.