Mandeep R. Mehra
Mandeep Rajinder Mehra
|Occupation||Professor at Harvard Medical School|
Medical Director of Brigham Heart and Vascular Center
Mandeep R. Mehra (born December 1967 in Delhi) is The William Harvey Distinguished Chair in Advanced Cardiovascular Medicine and a professor of medicine at Harvard Medical School. He is the Medical Director of the Brigham Heart and Vascular Center in Boston, Massachusetts and specializes in advanced heart failure, mechanical circulatory support and cardiac transplantation.
He has served as President of the International Society for Heart and Lung Transplantation (ISHLT) and is the Editor-in-Chief of the society's journal, the Journal of Heart and Lung Transplantation. He is also President of the Heart Failure Society of America.
Early life and career
Mandeep Rajinder Mehra was born in December 1967, the same day as heart surgeon Christiaan Barnard performed the world's first human-to-human heart transplant at Groote Schuur Hospital in Cape Town, South Africa. After graduating in medicine from the Mahatma Gandhi Institute of Medical Sciences in 1983, he pursued further studies in the United States with the ambition to qualify in cardiac catheterization.
Narrowing of the coronary arteries, or cardiac allograft vasculopathy (CAV), after a heart transplant has been noted as a significant problem in terms of long-term survival. The terminology used in past research has varied, causing difficulties in interpreting which treatments benefit. In 2010, Mehra led the first international consensus document from the ISHLT working group on the classification of CAV, standardising the nomenclature used and therefore defining the best way to identify CAV. His paper on allograft vasculopathy was accepted for presentation at the ISHLT in Venice.
His research focuses on the use of intravascular ultrasound and angioscopy in coronary artery disease after heart transplantation. In addition, he has interests in new immunosuppressive therapy in minority populations and the role of artificial hearts and bio-markers to assess diagnosis and treatment in heart failure. Other research persuits have included reducing side-effects of endomyocardial biopsys using genomic and proteonomic markers. He was also the first to define the association of suppressed natriuretic peptide expression in obesity.
He became the William Harvey Distinguished Chair in Advanced Cardiovascular Medicine and a professor of medicine at Harvard Medical School and Medical Director of the Brigham Heart and Vascular Center in Boston, Massachusetts. He specializes in advanced heart failure, mechanical circulatory support and cardiac transplantation.
He has published more than 400 manuscripts, abstracts, and book chapters in areas of immunosuppression, genomic medicine, cardiac transplant rejection, guidelines for listing patients for a heart transplant, and in mechanical circulatory support.
- "Contemporary concepts in prevention and treatment of cardiac allograft vasculopathy", American Journal of Transplantation, 23 March 2006, PMID 16686747, doi:10.1111/j.1600-6143.2006.01314.x
- "Healthcare Resource Use and Cost Implications in the MOMENTUM 3 Long-Term Outcome Study.", Circulation, (2018), doi:10.1161/CIRCULATIONAHA.118.035722.
- Current Advances in Heart Transplantation: An Issue of Heart Failure Clinics, Elsevier (2007), ISBN 978-1416043201.
- History of International Heart and Lung Transplantation, co-authored with James K. Kirklin and Lori J. West, Elsevier (2010).
- Clinical Challenges in Heart Failure, Clinical Pub Serv (2010), ISBN 9781846920448.
- Emergency Cardiac Care 2012: From the ED to the CCU, An Issue of Cardiology Clinics, co-authored with Amal Mattu, Elsevier Health Sciences (2012), ISBN 9781455748914.
- Oxford Textbook of Advanced Heart Failure and Cardiac Transplantation, co-authored with Michael J. Domanski and Marc A. Pfeffer, Oxford University Press (2016), (ISBN 978-0-19-873487-1.
- Chapter 12, "Management of Hypertension in Left Ventricular Systolic Dysfunction", co-authored with F. Siddiqi, and K. Thanavaro in Evidence-based Management of Hypertension, edited by Matthew R Weir, Gutenberg Press (2010), ISBN 9781908986542.
- The International Society for Heart and Lung Transplantation (31 March 2016), Mandeep R. Mehra, MBBS, FACC, FACP, retrieved 6 November 2018
- Administrator. "Dr Mandeep Mehra". www.mgims.ac.in. Retrieved 6 November 2018.
- Elsevier (2010). "New ISHLT Cardiac Allograft Vasculopathy Standardized Nomenclature: A Common International Definition Will Benefit Heart Transplant Patients". www.elsevier.com. Retrieved 12 November 2018.
- "New cardiac pump device more effective, less costly than standard pump: Analysis of data from MOMENTUM 3 trial finds Heartmate 3 can minimize cost of care over time for heart failure patients". ScienceDaily. Retrieved 12 November 2018.
- "Mandeep R Mehra, M.B.,B.S." Connects.catalyst.harvard.edu. Harvard Medical School. Retrieved 12 November 2018.
- "Dr. Mandeep R. Mehra, MD". Healthgrades.com. Retrieved 12 November 2018.
- "ISHLT Past Presidents". International Society for Heart and Lung Transplantation. Retrieved June 6, 2015.
- "Editorial Board". Jhltonline.org. Journal of Heart and Lung Transplantation. Retrieved June 6, 2015.
- "Medscape Log In". www.medscape.com. Retrieved 6 November 2018.(subscription required)
- "Executive Council". Heart Failure Society of America. Retrieved 6 June 2015.
- "Implementation Science and Global Connectivity: HFSA’s Path Forward", President's letter, HFSA, Journal of Cardiac Failure Vol. 22 No. 11 2016.