Dog with hair loss caused by demodectic mange
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Mange // is a class of skin diseases caused by parasitic mites. Since mites also infect plants, birds, and reptiles, the term "mange", suggesting poor condition of the hairy coat due to the infection, is sometimes reserved only for pathological mite-infestation of nonhuman mammals. Thus, mange includes mite-associated skin disease in domestic animals (cats and dogs), in livestock (such as sheep scab), and in wild animals (for example, coyotes, cougars, and bears). Since mites belong to the arachnid subclass Acari (also called Acarina), another term for mite infestation is acariasis.
Parasitic mites that cause mange in mammals embed themselves either in skin or hair follicles in the animal, depending upon their genus. Sarcoptes spp. burrow into skin, while Demodex spp. live in follicles.
Also called demodicosis or red mange, demodectic mange is caused by a sensitivity to and overpopulation of Demodex canis. The two types of demodectic mange are localized and generalized. Localized consists of four spots or less. It is not contagious to humans.
Arthur Stanley Hirst, a noted authority on Acari states "In typical cases of this complaint the mites are found in enormous numbers, but Friedrich Gmeiner and also Albert E. Mettam have shown that D. canis is not the actual cause of follicular mange, which is due to a bacterium Staphylococcus epidermidis or some allied form. The mite plays an important part in the disease, however, by preparing the ground for the invasion of the bacterium by dilating the follicles and sweat-glands, and possibly also carries and introduces the germ. Whilst the Acari remain in the follicles or sweat-glands some of the bacteria may penetrate more deeply and be conveyed from one point to another by the blood-stream." - "Studies on Acari No. 1. The Genus Demodex, Owen"
A type of demodectic infection in humans is known, but is less commonly symptomatic. See Demodex folliculorum.
Sarcoptic mange, also known as canine scabies, is a highly contagious infestation of Sarcoptes scabiei canis, a burrowing mite. The canine sarcoptic mite can also infest cats, pigs, horses, sheep, and various other species. The human analog of burrowing mite infection, due to a closely related species, is called scabies (the "seven year itch").
All these burrowing mites are in the family Sarcoptidae. They dig into and through the skin, causing intense itching from an allergic reaction to the mite, and crusting that can quickly become infected. Hair loss and crusting frequently appear first on elbows and ears. Skin damage can occur from the dog's intense scratching and biting. Secondary skin infection is also common. Dogs with chronic sarcoptic mange are often in poor condition, and in both animals and humans, immune suppression from starvation or any other disease causes this type of mange to develop into a highly crusted form in which the burden of mites is far higher than in healthy specimens.
Veterinarians usually attempt diagnosis with skin scrapings from multiple areas, which are then examined under a microscope for mites. Sarcoptes mites, because they may be present in relatively low numbers, and because they are often removed by dogs chewing at themselves, may be difficult to demonstrate. As a result, diagnosis in sarcoptic mange is often based on symptoms rather than actual confirmation of the presence of mites. A common and simple way of determining if a dog has mange is if it displays what is called a "pedal-pinna reflex", which is when the dog moves one of its hind legs in a scratching motion as the ear is being manipulated and scratched gently by the examiner; because the mites proliferate on the ear margins in nearly all cases at some point, this method works over 95% of the time. It is helpful in cases where all symptoms of mange are present but no mites are observed with a microscope. The test is also positive in animals with ear mites, an ear canal infection caused by a different but closely related mite (treatment is often the same). In some countries, an available serologic test may be useful in diagnosis.
Affected dogs need to be isolated from other dogs and their bedding, and places they have occupied must be thoroughly cleaned. Other dogs in contact with a diagnosed case should be evaluated and treated. A number of parasitical treatments are useful in treating canine scabies. Sulfurated lime (a mixture of calcium polysulfides) rinses applied weekly or biweekly are effective (the concentrated form for use on plants as a fungicide must be diluted 1:16 or 1:32 for use on animal skin).
Selamectin is licensed for treatment in dogs by veterinary prescription in several countries; it is applied as a dose directly to the skin, once per month (the drug does not wash off). A related and older drug ivermectin is also effective and can be given by mouth for two to four weekly treatments or until two negative skin scrapings are achieved. Oral ivermectin is not safe to use on some collie-like herding dogs, however, due to possible homozygous MDR1 (P-glycoprotein) mutations that increase its toxicity by allowing it into the brain. Ivermectin injections are also effective and given in either weekly or every two weeks in one to four doses, although the same MDR1 dog restrictions apply.
Topical 0.01% ivermectin in oil (Acarexx) has been reported to be effective in humans, and all mite infections in many types of animals (especially in ear mite infections where the animal cannot lick the treated area), and is so poorly absorbed that systemic toxicity is less likely in these sites. Nevertheless, topical ivermectin has not been well enough tested to be approved for this use in dogs, and is theoretically much more dangerous in zones where the animal can potentially lick the treated area. Selamectin applied to the skin (topically) has some of the same theoretical problems in collies and MDR1 dogs as ivermectin, but it has nevertheless been approved for use for all dogs provided that the animal can be observed for 8 hours after the first monthly treatment. Topical permethrin is also effective in both dogs and humans, but is toxic to cats.
Sarcoptic mange is transmissible to humans who come into prolonged contact with infested animals, and is distinguished from human scabies by its distribution on skin surfaces covered by clothing. For treatment of sarcoptic infection in humans, see scabies. For demodetic infection in humans, which is not as severe as it is in animals with thicker coats (such as dogs), see Demodex folliculorum.
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- Cheyletiella - This genus of mites causes dermatitis and itching in many groups of mammals, including pets and humans, but rarely causes hair loss, so is not usually considered clinically to cause "mange".
- "Mange – Definition and More from the Free Merriam-Webster Dictionary". Merriam-webster.com. 2010-08-13. Retrieved 2010-11-14.
- "mange" at Dorland's Medical Dictionary
-  Severe mite-caused mange in wild bears
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- Beugnet, Frédéric; de Vos, Christa; Liebenberg, Julian; Halos, Lénaïg; Larsen, Diane; Fourie, Josephus (2016). "Efficacy of afoxolaner in a clinical field study in dogs naturally infested with Sarcoptes scabiei". Parasite. 23: 26. doi:10.1051/parasite/2016026. ISSN 1776-1042. PMC . PMID 27317462.
- Beugnet, Frédéric; Halos, Lénaïg; Larsen, Diane; de Vos, Christa (2016). "Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis". Parasite. 23: 14. doi:10.1051/parasite/2016014. ISSN 1776-1042. PMC . PMID 27012161.
- Borgman W (June 30, 2006). Dog mange called scabies can transfer to humans. Orlando Sentinel archive. Retrieved February 16, 2015.
- Feline mange
- Red Mange (Demodicosis) on Veterinary Partner
- Demodectic mange in cats on Veterinary Partner
- Sarcoptic Mange on Veterinary Partner
- Sarcoptic Mange in the Pet Health Library
- Mange in Red Foxes (Wildlife Online)
- Bornstein, Set; Mörner, Torsten; Samuel, William M. (2001). "Sarcoptes scabiei and Sarcoptic Mange". In Samuel, William M.; Pybus, Margo J.; Kocan, A. Alan. Parasitic Diseases of Wild Mammals. pp. 107–19. ISBN 978-0-8138-2978-4.