Manidipine

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Manidipine
Manidipine.svg
Clinical data
Trade namesManyper, etc.
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC35H38N4O6
Molar mass610.711 g·mol−1
3D model (JSmol)

Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.[1][2][3][4][5]

It was patented in 1982 and approved for medical use in 1990.[6]

References[edit]

  1. ^ Cheer SM, McClellan K (2001). "Manidipine: a review of its use in hypertension". Drugs. 61 (12): 1777–99. doi:10.2165/00003495-200161120-00010. PMID 11693466. Archived from the original on 2013-01-17. Retrieved 2009-06-20.
  2. ^ McKeage K, Scott LJ (2004). "Manidipine: a review of its use in the management of hypertension". Drugs. 64 (17): 1923–40. doi:10.2165/00003495-200464170-00011. PMID 15329044. Archived from the original on 2013-01-16. Retrieved 2009-06-20.
  3. ^ Roca-Cusachs A, Triposkiadis F (2005). "Antihypertensive effect of manidipine". Drugs. 65 Suppl 2: 11–9. doi:10.2165/00003495-200565002-00003. PMID 16398058. Archived from the original on 2013-01-16. Retrieved 2009-06-20.
  4. ^ Otero ML (2007). "Manidipine-delapril combination in the management of hypertension". Vascular Health and Risk Management. 3 (3): 255–63. PMC 2293964. PMID 17703633.
  5. ^ Mizuno K, Haga H, Takahashi M, Fukuchi S (August 1992). "Evaluation of manidipine hydrochloride, a new calcium antagonist, in the treatment of hypertensive patients with renal disorders". Current Therapeutic Research. 52 (2): 248–253. doi:10.1016/S0011-393X(05)80475-8.
  6. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 465. ISBN 9783527607495.