Manokin River is a river in Somerset County, Maryland, that flows into Tangier Sound, an arm of the Chesapeake Bay. The Manokin (local //) rises east of Princess Anne, Maryland, flows through the town, then widens into a tidal estuary. Tributaries along the river's 17-mile (27 km) length are Kings Creek, Back Creek, St. Peters Creek, Broad Creek, and Fishing Creek. During the colonial period, the Manokin was navigable as far as Princess Anne.
The Manokin Historic District is located on both sides of the river near its mouth.