Manuel Casanova

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Manuel Casanova
Manuel Casanova.jpg
Born
Manuel Casanova
NationalityAmerican
Alma materJohns Hopkins
Known forSmartState Chair in Childhood neurotherapeutics
AwardsThe Outstanding Scholar Award
Frontiers Media Spotlight Award
Scientific career
FieldsChildhood Neurotherapeutics
InstitutionsUniversity of South Carolina Greenville
WebsiteOfficial website

Manuel F. Casanova is the SmartState Endowed Chair in Childhood Neurotherapeutics and a professor of Biomedical Sciences at the University of South Carolina School of Medicine Greenville. He is a former Gottfried and Gisela Kolb Endowed Chair in Outpatient Psychiatry and a Professor of Anatomical Sciences and Neurobiology at the University of Louisville.[1]

Casanova has four daughters: Cristina, Sabrina, Belinda, and Melina. He has a personal blog titled "Cortical Chauvinism".[2]

Education and early career[edit]

Casanova earned his medical degree from the University of Puerto Rico. He then completed clinical and research fellowships at Johns Hopkins University School of Medicine, including three years in neuropathology, where he was in-charge of pediatric neuropathology, which was when his interest in developmental disorders of the brain arose. He subsequently helped establish two brain banks, the Johns Hopkins Brain Resource Center and the Brain Bank Unit of the Clinical Brains Disorders Branch at the National Institute of Mental Health (NIMH).

Casanova spent several years as a deputy medical examiner for Washington, D.C., where he gained experience with the postmortem examination of sudden infant death syndrome and child abuse, which was when he began publishing extensively on postmortem techniques, including neuronal morphometry immunocytochemistry, neurochemistry, and autoradiography. He also worked as a consultant and was staff neuropathologist at Sinai Hospital in Maryland, the North Charles Hospital, and the D.C. General Hospital. He is also a former lieutenant commander in the US Public Health Service. After serving as a professor of psychiatry and neurology at the Medical College of Georgia, he subsequently joined the University of Louisville faculty.[1]

Research[edit]

Casanova's recent research projects have examined brain abnormalities in patients with language disturbances, including autism spectrum disorders and dyslexia. His interest has gradually come to focus on abnormalities of cortical neurocircuitry, in particular on the cell minicolumn, a vertical conglomerate of eighty to one hundred neurons that have in common a latency of response to stimulation.[3] Using computerized imaging analysis, he has established the anatomical validity of the cell minicolumn. Casanova has reported interhemispheric differences in the morphometry of minicolumns that could provide explanations for the speciation of hominids. Localized in Brodmann area 22—part of Wernicke’s language region—the morphometric difference may play a role both in the development of language and in related disorders.[2]

His neuromorphology research, conducted in collaboration with other researchers from around the globe, has found there are drastic differences in the brains of autistic individuals. The studies that he conducted show that minicolumns (or 'brain strands') of autism spectrum individuals have more cells, but they are narrower and more densely packed, which he says can limit the brain's ability to send messages.[4] Casanova claimed this helps explain symptoms since "there's not enough juice to actually power very long connections in the brain".[5]

Recognition[edit]

His expertise in the field of postmortem techniques was recognized by honorary appointments as a Scientific Expert for the Armed Forces Institute of Pathology and as a Professorial Lecturer for the Department of Forensic Science at George Washington University.[6]

Awards[edit]

  • Presidential Award of the American Medical Association, Puerto Rico Chapter (1981) [7]
  • Physician's Recognition Award by the American Medical Association (1982-5)
  • National Research Service Award (1984-6)
  • Stanley Scholar (1994)
  • Distinguished Faculty, The Medical College of Georgia (1995)
  • Scientific Advisory Board, National Alliance for Autism Research (1996)
  • Tissue Advisory Board, Autism Tissue Board (1999-2000)
  • Senior Scientist Award, 11th Biennial Winter Workshop on Schizophrenia (2002)
  • Distinguished Clinical Research Award, Medical College of Georgia (2003)
  • Gottfried and Gisela Kolb Endowed Chair in Psychiatry (2003)
  • Chairperson, NIH-CSR Developmental Brain Disorders Study Section (2007-9)
  • Magisterial Presentation. Third World Congress of Autism (2010)
  • Contributing Piece Award presented by Families for Effective Autism Treatment (FEAT) (2011)
  • Opening Speaker for the International Symposium 2012 of the FRA/CIBERER on Advances in the Biomedical Research of Autism Spectrum Disorders (2012)
  • Member of the Scientific Advisory Committee for Generation Rescue (2013)
  • Magisterial presentation. XV Simposio de investigaciones en salud: discapacidad y ciclo vital (2013)
  • Honorary Professor the International Autism Institute (2013)
  • Scientific Advisory Board, Clearly Present Foundation (2013)
  • Scientific Advisory Board, Center for Advanced Diagnostics, Evaluation, and Therapeutics, LLC (2013)
  • Miembro equipo fundador: Autismo Colombia (2014)
  • Scientific Advisory Board, Autism Research Institute, San Diego CA (2015)
  • Honorary Doctor of Krasnoyarsk State Pedagogical University (2015)
  • Visiting Professor of the Krasnoyarsk State Medical University (2015)
  • President elect, International Consortium of Autism Institutes (2016)
  • Special Recognition, Distinguished Seminar Series, University of Louisville (2016)
  • Advisory Board, Our Sunny World, Russia (2017)
  • Member of the Irlen International Professional Advisory Board (2017)
  • The Outstanding Scholar Award[8] (2017)
  • Frontiers Spotlight Award[9] (2017)

Views on neurodiversity[edit]

Casanova has claimed that some members of the neurodiversity movement compare his research to genocide. He has received disparaging phone calls and emails, and even death threats.[10] Casanova also points out that parents that support therapy or treatment for autistic children say that it will reduce their suffering and give them the best chance to succeed in adulthood, because they claim that it is not possible for society to accommodate autistics.[11] In a journal article, Casanova criticized neurodiversity advocates for ignoring the roles of Leo Kanner and Bernard Rimland in advocating for accommodations, claiming that this is because those individuals also wanted medical treatments for autism.[12] He also claimed that Neurotribes, a book written from the neurodiversity perspective, was unfairly weighted against Leo Kanner.[13]

Selected works[edit]

Books[edit]

  • Casanova, Manuel F.; Casanova, Emily (2018). Defining Autism: A Guide to Brain, Biology, and Behavior. Jessica Kingsley Publishers. ISBN 9781785927225.
  • Casanova, Manuel F.; El-Baz, Ayman; Suri, Jasjit S. (2017). Autism Imaging and Devices. CRC Press. ISBN 9781498709828.
  • Casanova, Manuel F.; Opris, Ioan (2015). Recent Advances on the Modular Organization of the Cortex. Springer. ISBN 9789401799003.
  • Casanova, Manuel F.; El-Baz, Ayman S.; Suri, Jasjit S. (2013). Imaging the Brain in Autism. Springer Science & Business Media. ISBN 9781461468431.
  • Casanova, Manuel F. (2008). Asperger's Disorder. New York, NY: Informa Healthcare. ISBN 9780849383601.
  • Casanova, Manuel F. (2005). Recent Developments in Autism Research. Nova Publishers. ISBN 9781594544972.
  • Casanova, Manuel F. (2005). Neocortical Modularity and the Cell Minicolumn. Nova Biomedical Books. ISBN 9781594543012.

Publications[edit]

  • Casanova MF, Casanova EL, Sokhadze EM. Dyslexia and autism: neuropathological differences pointing towards a spectrum of cognitive abilities. The Dyslexia Handbook 2018. Penrose Group, London, pp. 63-70, 2018.
  • Casanova MF, Lebedev MA, and Opris I (eds), "Augmentation of brain function: facts, fiction and controversy", Front Syst Neurosci, 2017
  • Casanova MF, Opris I, Sokhadze E, Casanova EL. Systems Theory, Emergent Properties, and the Organization of the Central Nervous System. In Opris I and Casanova MF (eds.). Physics of the Mind and Brain Disorders. Springer Publishing Company, New York, ch 3, pp. 55-68, 2017.
  • Casanova MF, Casanova EL, Sokhadze EM, "Leo Kanner, the Anti-psychiatry movement and Neurodiversity", Siberian Journal of Special Education, 1-2(16-17), 6-9, 2016 (in press)
  • Casanova MF, Casanova EL. Self-Injurious Behavior, Aggression, and Epilepsy in Autism Spectrum Disorders. In SM Edelson (ed): Understanding and treating self-injurious behavior in autism. Jessica Kingsley Publishers, London:England, Chapter 3, 2016.
  • Casanova MF, Casanova E. Gene pentrance in autism (editorial). Autism Research Review International 29 (3), 2015.
  • Casanova MF. The minicolumnopathy of autism. In Casanova MF, Opris I (eds) Recent advances on the modular organization of the cortex. Springer Publishing Co, ch 13, pp 225-238, 2015.
  • Casanova MF. Vernon Benjamin Mountcastle. In Casanova MF, Opris I (eds) Recent advances on the modular organization of the cortex. Springer Publishing Co, ch 2, pp 7-14, 2015.
  • Casanova MF, Opris I. Introduction: Recent advances in the modular organization of the cortex. Springer, ch.1, pp 1-6, 2015.
  • Casanova MF, Opris I (eds) Recent advances on the modular organization of the cortex. Springer Publishing Co, 2015.
  • Casanova MF, Amaral DG, Rubenstein JLR, Rogers SJ. Neuroscience of Autism. In Allan Tasman, Jeffrey Liberman, Jerry Kay, Michael First, and Michelle Riba (eds) Psychiatry, Wiley and Sons: 4th edition, ch. 23, 2015.
  • Casanova MF. The neuropathology of autism. In SH Fatemi (ed) The Molecular Basis of Autism, SpringerScience:New York, ch. 8, pp 153-171, 2015.
  • Casanova MF, Sokhadze E, Opris I, Wang Y, Li X. Autism spectrum disorders: linking neuropathological findings to treatment with transcranial magnetic stimulation. Acta Paediatrica 104(4):346-55, 2015.
  • Casanova EL, Casanova MF. Genetic studies indicate that neural induction and early neuronal maturation are disturbed in autism. Front Cell Neurosci 8:397, 2014. PMID: 25477785
  • Casanova MF, Dombroski B, Switala AE. Imaging and the corpus callosum in patients with autism. In The Comprehensive Guide to Autism. Springer:New York, pp. 947-962, 2014.
  • Casanova EL and Casanova MF. Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism. Frontiers in Cellular Neuroscience, 2014 Nov 19;8:397. doi: 10.3389/fnhum.2014.01034.
  • Casanova MF. La Neurobiologia del Autismo. In Maria Merino Martinez (ed) todo Sobre el Asperger. Publicaciones Altaria, Tarragona, capitulo 2, p. 53-76, 2014.
  • Casanova MF, Sokhadze E. Transcranial Magnetic Stimulation: Application in Autism treatment. Valerie Hu (ed) in Frontiers in Autism Research: New Horizons for Diagnosis and Treatment. World Scientific Publishing Company, New Jersey, ch.23, pp. 583-606, 2014.
  • Casanova MF. The neuropathology of autism. In Fred Volkmar, Kevin Pelphrey, Rhea Paul, Sally Rogers (eds). Handbook of Autism and Pervasive Developmental Disorders 4th edition, ch. 21. Pp. 497-531, 2014.
  • Casanova MF, Hensley M, Sokhadze EM, El-Baz A, Wang Y, Li X, Sears L. Effects of weekly low-frequency rTMS on autonomic measures in children with autism spectrum disorder, Frontiers in Human Neuroscience, 8:851. Doi:10.3389/fnhum.2014.00851. eCollection 2014.
  • Casanova MF. The modular organization of the cerebral cortex: minicolumns and minicolumnopathies. The Siberian Journal of Special Education, Thematic Issue: International Experience of Education and Socialization of Children and Adults with Autism, 1(13): 9-13, 2014. ISSN: 2221-1160
  • Casanova MF. Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias. Medical Hypothesis, 83(1):32-8, 2014.
  • Casanova MF. Neural mechanisms in autism. In Fred Volkmar (ed.) Encyclopedia of Autism Spectrum Disorders, Springer:New York, pp. 1994-2007, 2013.
  • Casanova MF, Baruth J, El-Baz AS, Sokhadze GE, Hensley M, Sokhadze ES. Evoked and induced gamma frequency oscillations in autism. In Casanova MF, El-Baz AS, Suri JS (eds) Imaging the Brain in Autism. Springer:New York, ch.5, pp. 87-106, 2013.
  • Casanova MF, Pickett J. The Neuropathology of Autism. In Casanova MF, El-Baz A, Suri JS (eds) Imaging the Brain in Autism. Springer: New York, ch.2, pp.27-44, 2013.
  • Casanova MF, Patterson PH, London E. Introduction to Neuropathology. Casanova MF, El-Baz AS, Suri JS (eds) Imaging the Brain in Autism. Springer: New York, ch. 1, pp. 1-26, 2013.
  • Casanova MF. The minicolumnopathy of autism. In J Buxbaum and P Hof (editors): The Neuroscience of Autism Spectrum Disorders, Academic Press:Oxford, chapter 3.7, pp. 327-333, 2013.
  • Casanova MF. Canonical circuits of the cerebral cortex as enablers of neuroprosthetics. Special Issue on Augmentation of Brain Function: Facts, Fiction and Controversy. Frontiers in Systems Neuroscience, 7(77):1-3, 2013.
  • Casanova MF, AS, Kamat SS, Dombroski BA, Khalifa F, Elnakib A, Soliman A, Allison-McNutt A, Switala AE. Focal cortical dysplasias in autism spectrum disorder. Acta Neuropathologica Communications 1:67, 2013. doi:10.1186/2051-5960-1-67
  • Casanova MF, Baruth JM, El-Baz AS, Tasman A, Sears L, Sokhadze EM. Repetitive TMS (rTMS) modulates ERP indices of attention in autism. Translational Neuroscience, 3(2): 170-180, 2012.
  • Casanova MF, Sokhadze E, El-Baz A, Baruth J, Mathai G, Sears L. Research at the University of Louisville Autism Center. Cutting Edge Therapies for Autism 2. Skyhorse Publishing, 425-429, 2011.
  • Casanova MF, El-Baz A, Switala A. Laws of conservation as related to brain growth, aging, and evolution: symmetry of the minicolumn. Frontiers in Neuroanatomy, 5:66, 2011.
  • Casanova MF, Starkstein S, Jellinger K. Clinicopathological correlates of behavioral and psychological symptoms of dementia. Acta Neuropathologica, 122(2): 117-135, 2011.
  • Casanova MF, El-Baz A, Switala AE, Williams EL, Williams, D, Minshew N, Conturo T. A quantitative analysis of the shape of the corpus callosum in autism. Autism, 15(2): 223-238, 2011.
  • Casanova MF, Williams EL. Prenatal Ultrasound: It’s Not Just a Photograph. Autism Science Digest, 1: 58-60, 2011.
  • Casanova MF, Sokhadze E, El-Baz A, Baruth J, Mathai G, Sears L. Research at the University of Louisville Autism Center. Siri K and Lyons T (eds). Cutting Edge Therapies for Autism, Skyhorse Publishing: New York, ch. 68, pp. 410-413, 2010.
  • Casanova MF, El-Baz A, Elnakib A, Giedd H, Rumsey H, Williams EL, Switala AE. Corpus callosum shape analysis with application to dyslexia. Translational Neuroscience, 1(2):124-130, 2010.
  • Casanova MF. The role of the entorhinal cortex in paraphrenia. Current Psychiatry Reports, 12(3): 202-207, 2010.
  • Casanova MF. The pathology of paraphrenia. Current Psychiatry Reports 12(3): 196-201, 2010.
  • Casanova MF, El-Baz A, Vanbogaert E, Narahari P, Switala A. Minicolumnar core width by lamina comparisons between autistic subjects and controls. Brain Pathology 20(2): 451-458, 2010.
  • Casanova MF. Cortical organization: a description and interpretation of anatomical findings based on systems theory. Translational Neuroscience, 1(1): 62-71, 2010.
  • Casanova MF, Tillquist C, Trippe J, Switala A. Radial bias in structure of dolphin insular cortex likely reflects minicolumnar organization characteristic of mammalian neocortex. Translational Neuroscience, 1(1): 37-42, 2010.
  • Casanova MF, Trippe J. Radial cytoarchitecture and patterns of connectivity in autism. F. Happe and U Frith (eds) Autism and Talent. Oxford University Press: Oxford, ch. 11, pp. 135-140, 2010.
  • Casanova MF, El-Baz A, Vanbogaert E, Narahari P, Trippe J. Minicolumnar width: comparison between supragranular and infragranular layers. J Neuroscience Methods, 184(1):19-24, 2009.
  • Casanova MF, El-Baz A, Giedd J, Rumsey JM, Switala A. Increased white matter gyral depth in dyslexia: implications for corticortical connectivity. Journal of Autism and Developmental Disorders 40(1): 21-29, 2009.
  • Casanova MF. La esquizofrenia como condicion neurologica debido a una falta en la lateralizacion del cerebro: observaciones micro- y macroscopicas. Revista de Neurologia, 49(3): 136-142, 2009.
  • Casanova MF, Trippe J. Radial cytoarchitecture and patterns of cortical connectivity in autism. Proceedings of the Royal Society 364: 1433-1436, 2009.
  • Casanova MF, Trippe J, Tillquist C, Switala A. Morphometric variability of minicolumns in the striate cortex of Homo sapiens, Macaca mulatta, and Pan troglodytes. Journal of Anatomy 214(2): 226-234, 2009.
  • Casanova MF, El-Baz A, Mott M, Mannheim G, Hassan H, Fahmi R, Rumsey JM, Switala AE, Farag A. Reduced gyral window and corpus callosum size in autism: possible macroscopic correlates of a minicolumnopathy. Journal of Autism and Developmental Disorders 39(5): 619-34, 2009
  • Casanova MF. The significance of minicolumnar size variability in autism: a perspective from comparative anatomy. In A Zimmerman (ed) Autism Current Theories and Evidence, Current Clinical Neurology, The Human Press, Inc., ch. 16, pp. 349-360, 2008.
  • Casanova MF, Konkachbaev AI, Switala AE, Elmaghraby AD. Recursive trace line method for detecting myelinated bundles: a comparison study with pyramidal cell arrays. Journal of Neuroscience Methods, 168(2):367-372, 2008.
  • Casanova MF, Tillquist C. Encephalization, emergent properties, and psychiatry: a minicolumnar perspective. The Neuroscientist, 14:101-118, 2008.
  • Casanova MF. The minicolumnopathy of autism: a link between migraine and gastrointestinal symptoms. Medical Hypothesis, 70:73-80, 2008.
  • Casanova MF, Kreczmanski P, Trippe J, Switala A, Heinsen H, Steinbusch HWM. Schmitz S. Neuronal distribution in the neocortex of schizophrenic patients. Psy Res 158(3):266-277, 2008.
  • Casanova MF, Steele J. Autism: An Overview. Louisville Medicine, Louisville Medicine. The Greater Louisville Medical Society 54(11): 503-505, 531, 2007.
  • Casanova MF. The neuropathology of autism. Brain Pathology 17(4): 422-33, 2007.
  • Casanova MF. Schizophrenia as a deficit in the modulation of cortical minicolumns by monoaminergic systems. International Review of Psychiatry 19(4): 361-372, 2007.
  • Casanova MF, Switala AE, Trippe J, Fitzgerald M. Comparative minicolumnar morphometry of three distinguished scientists. Autism 11(6):557-569, 2007.
  • Casanova MF, Trippe J, Switala AE: A temporal continuity to the vertical organization of the human neocortex: a study spanning prenatal development and aging. Cerebral Cortex, 17(1):130-137, 2007.
  • Casanova MF, Switala A, Trippe J. A comparison study on the vertical bias in neocortex and hippocampus. Developmental Neuroscience, 29(1-2):193-200, 2007.
  • Casanova MF, Mott M. The neuropathology of autism: a selective review. Journal of Special Education and Rehabilitation 1(3-4):21-35, 2006.
  • Casanova MF, Farag A, El-Baz A, Mott M, Hassan H, Fahmi R, Switala AE. Abnormalities of the Gyral Window in Autism: A Macroscopic Correlate to a Putative Minicolumnopathy. Journal of Special Education and Rehabilitation 1(1-2):85-101, 2006.
  • Casanova MF, van Kooten IAJ, Switala AE, van Engeland H, Heinsen H, Steinbusch HWM, Hof PR, Trippe J, Stone J, Schmitz C. Minicolumnar abnormalities in autism. Acta Neuropathologica 112(3):287-303, 2006.
  • Casanova MF, Trippe JT II, Switala AE, "A temporal continuity to the vertical organization of the human neocortex", Cerebral Cortex, 2006 (in press)
  • El-Zehiry N, Casanova MF, Hassan H, Farag AA, "Effect of minicolumnar disturbance on dyslexic brains: an MRI study", Biomedical imaging: Macro to nano, 1336-1339, 2006
  • Casanova MF, Trippe JT II, "Regulatory mechanisms of cortical laminar development", Brain research: Brain research reviews, 2006; 51(1), 72–84.
  • Chance SA, Casanova MF, Switala AE, Crow TJ, Esiri MM, "Minicolumn thinning in temporal lobe association cortex but not primary auditory cortex in normal human ageing", Acta Neuropathologica, 2006; 111(5), 459–464
  • Kruesi MJP, Casanova MF, White matter in liars", The British Journal of Psychiatry, 2006; 188(3), 293–294
  • Seelan RS, Janckila AJ, Parthasarathy RN, Casanova MF, "The importance of using equimolar DNA for transfection analysis of the 5′ flanking promoter regions of genes", Analytical Biochemistry, 2006; 349(2), 306–308
  • Casanova MF, (editor). Recent developments in autism research, Hauppauge, New York: Nova Science Publishers, 2005.
  • Casanova MF, (editor), Neocortical modularity and the cell minicolumn, Hauppauge, New York: Nova Science Publishers, 2005
  • Konkachbaev AI, Casanova MF, Graham JH, Elmaghraby AS, "Automated recursive segmentation of large neocortical images using standard deviation as termination criteria", 27th Annual International Conference of the Engineering in Medicine and Biology Society, 2531-2534, 2005
  • Casanova MF, "Anomalías en los circuitos corticales en los cerebros de pacientes con autismo", in: Martos J, González PM, Llorente M, Nieto C, eds. Nuevos desarrollos en autismo: el futuro es hoy, 345-371. Madrid, Librería Paradox, 2005
  • Konkachbaev AI, Elmaghraby AS, Casanova MF, "Recursive segmentation of minicolums using myelinated bundles", Proceedings of the 2nd International IEEE EMBS Conference on Neural Engineering, 52-55, 2005
  • Casanova MF, de Zeeuw L, Switala AE, Kreczmanski P, Korr H, Ulfig N, Heinsen H, Steinbusch HWM, Schmitz C, "Mean cell spacing abnormalities in the neocortex of patients with schizophrenia", Psychiatry Research, 133(1):1-12, 2005
  • Kruesi MJP, Casanova MF, Mannheim G, Johnson-Bilder A, "Reduced temporal lobe volume in early onset conduct disorder", Psychiatry research: Neuroimaging, 132(1):1-11, 2004
  • Buxhoeveden DP, Casanova MF, "Accelerated maturation in brains of patients with Down syndrome", Journal of Intellectual Disability Research, 48(7):704-705, 2004
  • Casanova MF, "White matter volume increase and minicolumns in autism", Annals of Neurology, 56(3):453, 2004
  • Casanova MF, Araque J, Giedd J, Rumsey JM, "Reduced brain size and gyrification in the brains of dyslexic patients", Journal of Child Neurology, 19(4):275-281, 2004
  • Roy E, Casanova MF, Jerath V, "Autistic poetry as therapy", Journal of Poetry Therapy, 17(1):33-38, 2004
  • Casanova MF, "Intracortical circuitry: One of Psychiatry’s missing assumptions", European Archives of Psychiatry and Clinical Neuroscience, 254(3):148-151, 2004
  • Casanova MF, Araque J, "Mineralization of the basal ganglia: implications for neuropsychiatry, pathology and neuroimaging", Psychiatry Research, 121(1):59-87, 2003
  • Casanova MF, Buxhoeveden DP, Gomez J, "Disruption in the inhibitory architecture of the cell minicolumn: implications for autism", The Neuroscientist, 9(6):496-507, 2003
  • Casanova MF, Lindzen EC, "Changes in gray-/white-matter ratios in the parahippocampal gyri of late-onset schizophrenia patients", American Journal of Geriatric Psychiatry, 11(6):605-9, 2003
  • Casanova MF, "Modular concept of brain organization and the neuropathology of psychiatric conditions", Psychiatry Research, 118(1):101-102, 2003.
  • Casanova MF, Buxhoeveden DP, Switala AE, Roy E., "Rett syndrome as a minicolumnopathy", Clinical Neuropathology, 22:163-168, 2003.
  • Casanova MF, "Preservation of hippocampal pyramidal cells in paraphrenia", Schizophrenia Research, 62(1-2):141-146, 2003.
  • Casanova MF, Buxhoeveden DP, Brown C, "Clinical and macroscopic correlates of minicolumnar pathology in autism", Journal of Child Neurology, 17:692-695, 2002
  • Casanova MF, Buxhoeveden DP, Switala AE, Roy E., "Neuronal density and architecture (gray level index) in the brains of autistic patients", Journal of Child Neurology, 17(7):515-521, 2002
  • Buxhoeveden DP, Casanova MF, "The minicolumn and evolution of the brain: a review", Brain, Behavior and Evolution, 60(3):125-151, 2002
  • Casanova MF, Kruesi M, Mannheim G., "Hippocampal pathology in two mentally ill paraphiliacs", Psychiatry Research: Neuroimaging, 115(1-2):79-89, 2002.
  • Casanova MF, Rothberg B, "Shape distortion of the hippocampus: a possible explanation for the reported pyramidal cell disarray in schizophrenia", Schizophrenia Research, 55(1-2):19-24, 2002
  • Buxhoeveden DP, Casanova MF, "The minicolumn hypothesis in neuroscience", Brain, 125(5):935-951, 2002.
  • Casanova MF, Buxhoeveden DP, Cohen M, Switala AE, Roy E., "Minicolumnar pathology in dyslexia", Annals of Neurology, 52:108-110, 2002.
  • Casanova MF, Buxhoeveden DP, Switala AE, Roy E., "Asperger’s syndrome and cortical neuropathology", Journal of Child Neurology, 17(2):142-145, 2002.
  • Casanova MF, Buxhoeveden DP, Switala AE, Roy E. Minicolumnar pathology in autism. Neurology, 58:428-432, 2002.
  • Casanova MF, Stevens J, Brown R, Royston C, Bruton C., "Disentangling the pathology of schizophrenia and paraphrenia", Acta Neuropathologica, 103:313-320, 2002
  • Buxhoeveden, D; Fobbs, A; Roy, E; Casanova, M (2002-01-01). "Quantitative comparison of radial cell columns in children with Down's syndrome and controls". Journal of Intellectual Disability Research. 46 (1): 76–81. doi:10.1046/j.1365-2788.2002.00362.x. ISSN 1365-2788.

References[edit]

  1. ^ a b Casanova, Manuel. "Clinical Professors". Clemson University. Retrieved 18 April 2016.
  2. ^ a b Casanova, Manuel. "Manuel F. Casanova, M.D." Minicolumn. Casanova and Switala. Retrieved 6 January 2016.
  3. ^ Denworth, Lydia (24 September 2015). "Brain Stimulation Holds Promise in Autism Treatment". Newsweek. Retrieved 8 January 2016.
  4. ^ Casanova, M F.; Buxhoeveden, DP; Switala, AE; Roy, E (12 February 2002). "Minicolumnar pathology in autism". Neurology. 58 (3): 428–32. doi:10.1212/wnl.58.3.428. PMID 11839843.
  5. ^ Lyle, Lori. "UofL Neuroscientist So Close To Autism Breakthrough He's Helping Fund Research". WAVE3. Retrieved 18 April 2016.
  6. ^ "Manuel Casanova". Autism Speaks. Retrieved 8 January 2016.
  7. ^ Casanova, Manuel. "CV" (PDF). Clemson. Retrieved 7 October 2018.
  8. ^ "2017 Faculty & Staff Awards". School of Medicine Greenville. Retrieved 7 June 2017.
  9. ^ Communications, Frontiers (14 June 2017). "Creating human super intelligence: winner of Spotlight Award 2017". Frontiers Blog. Retrieved 20 June 2017.
  10. ^ Hayasaki, Erika. "The Debate Over an Autism Cure Turns Hostile". Newsweek. Retrieved 18 April 2016.
  11. ^ Casanova, Manuel. "Neurodiversity" (PDF). Greenville Health System. Retrieved 19 March 2017.
  12. ^ Casanova, Manuel; Casanova, Emily (2016). "Leo Kanner, the Anti-Psychiatry Movement and Neurodiversity". Siberian Journal of Special Education. 1–2 (16–17): 6–9. Retrieved 18 April 2016.
  13. ^ Harris, James C. (August 2016). "Book forum". Journal of the American Academy of Child & Adolescent Psychiatry. 55 (8): 729–735. doi:10.1016/j.jaac.2016.06.004. Retrieved 19 March 2017.

External links[edit]

  • Manuel Casanova - Professor of Psychiatry, University of Louisville Google Scholar Profile
  • WAVE3.com - 'UofL Neuroscientist So Close To Autism Breakthrough He's Helping Fund Research', Lori Lyle, (July 14, 2006)
  • Cortical Chauvinism - Blog of Manuel Casanova, discussing issues related to autism.