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Marcello Crescenzi (1500 – 28 May, 1552) was an Italian Roman Catholic bishop and cardinal.
Marcello Crescenzi was born in Rome in 1500, the son of Mario Crescenzi and Pantasilea Capodiferro.
He became a doctor of both laws. He was a canon of Santa Maria Maggiore. In 1525, he was made an Auditor of the Roman Rota.
On January 19, 1534, he was elected Bishop of Marsi. He resigned the government of the diocese sometime before May 17, 1546.
Pope Paul III made him a cardinal priest in the consistory of June 2, 1542. He received the red hat and the titular church of San Marcello al Corso on November 6, 1542.
On November 2, 1544, the pope appointed Cardinal Crescenzi to the Council of Trent. On May 5, 1546, he became administrator of the see of Conza, holding that position until his death.
He was a cardinal elector at the papal conclave of 1549-50 that elected Pope Julius III. The new pope made Crescenzi papal legate in Bologna. He was the Camerlengo of the Sacred College of Cardinals from January 19, 1551 to January 8, 1552. The pope named him to a commission on church reform on February 18, 1551, and on March 4, 1551 named him legate a latere to the Council of Trent.
He died in Verona as he was returning to Rome from Trent on May 28, 1552. His remains were returned to Rome and he was buried in Santa Maria Maggiore.