Sir William Gascoigne VI: married firstly Alice Frognall and secondly Margaret Nevill (daughter of Richard Nevill, 2nd Baron Latimer of Snape). Had issue by both marriages. Second son by first marriage, Sir Henry Gascoigne, was ancestor of the Wyvill Baronets (from the 3rd onwards). His daughter Margaret married Sir Thomas Middleton, of Stockeld. Male line by primogeniture ended with his grandson William Gascoigne VIII, whose only daughter and heiress (other children died young) Margaret (1530–1592/93) who became the paternal grandmother of Thomas Wentworth, 1st Earl of Strafford.
Margaret or Margery (c. 1473 – 1515): married Ralph Ogle, 3rd Baron Ogle, and had issue.
Elizabeth (1470–1559): married before April 1493 as his second wife Sir George Tailboys (c. 1467 – 1538), de jure 9th Baron Kyme and Sheriff of Lincolnshire, grandson of Sir William Tailboys, de jure 7th Baron Kyme.
Anne or Agnes (c. 1474 – 1504): married firstly Sir Thomas Fairfax (c. 1475 – 1520). She had twin sons: Nicholas and William. Married secondly Ralph Nevill, of Thornton Bridge.
Dorothy (c. 1475 – 1527): married Sir Ninian Markenfield (died 1527).