Margaret Tisdale (née Breeze; 10 September 1950 – 29 April 2015) was a Welsh-born clinical virologist known for her studies of antiviral resistance in HIV and influenza virus, and for coordinating the development of the anti-influenza drug zanamivir.
Tisdale spent 33 years as a researcher at the Wellcome Research Laboratories, GlaxoWellcome and GlaxoSmithKline, where she eventually became head of clinical virology. She was an expert in HIV drug resistance and in optimising antiretroviral therapy. Tisdale headed the development of the influenza neuraminidase inhibitor zanamivir, which Glaxo licensed from Biota in 1990. She established the global Neuraminidase Inhibitor Susceptibility Network in 1999 to track resistance to neuraminidase inhibitors in clinical strains of influenza virus. She also published on antiviral drugs against rhinovirus, which causes the common cold.
- M Tisdale, SD Kemp, NR Parry, BA Larder (1993). Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America 90: 5653–56
- M Tisdale, T Alnadaf, D Cousens (1997). Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89. Antimicrobial Agents and Chemotherapy 41: 1094–98
- M Tisdale (2000). Monitoring of viral susceptibility: new challenges with the development of influenza NA inhibitors. Reviews in Medical Virology 10: 45–55
- "Gone in 2015: Commemorating 10 Outstanding Women in Science". Scientific American Blog Network. Retrieved 2016-01-19.
- "Tributes paid to Montgomeryshire scientist Margaret Tisdale who has died, aged 64". Denbighshire Free Press. 2015-05-28. Retrieved 2016-01-19.
- DJ Bauer; JWT Selway; JF Batchelor; M Tisdale; IC Caldwell; DAB Young (1981), "4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound", Nature, 292: 369–70, doi:10.1038/292369a0
- Sarah Knapton (27 January 2016), "Antidepressants can raise the risk of suicide, biggest ever review finds", The Daily Telegraph, retrieved 31 January 2016