Marian offers 18 AP (Advanced Placement) courses which are eligible for college credit. AP courses offered for the 2014-2015 school year include: AP English Language and Composition, AP English Literature and Composition, AP World History, AP U.S. Government and Politics, AP U.S. History, AP Micro Economics, AP Latin, AP Psychology, AP Calculus-AB, AP Calculus-BC, AP Statistics, AP Biology, AP Chemistry, AP Physics 1, AP Physics-BC Mechanics, AP Physics-BC Electricity and Magnetism, and AP Studio Art-2D. In addition, Marian offers ACP(Advanced College Project) classes through IUSB and non-AP dual credit courses through Ivy Tech Community College. These include Biology, Chemistry, U.S. History, Cadet Teaching, English, Calculus, and Physics I.
Marian's band includes both pep and concert band, which compete annually in the ISSMA competitions. The band performs during athletic events, as well as holding both a Christmas and Spring concert annually. As of April 2015[update], the school does not have a marching band.
Marian offers over 30 clubs and allows students to create new clubs. The current list includes ACTS (A Chance To Serve), Regina Caeli, Right to Life, Ambassadors/Student Leadership, Art Club, Bowling League, Drama, Latin, French, German, Spanish, Intramurals, Jr. Civitan, Liturgical Choir, Mock Trial, National Honors Society, Newspaper (The Lance), Pep, Quiz Bowl, SADD, Science Club, Ski, Speech and Debate, Student Council, Yearbook, Creative Writing, Dance, Diversity Coalition, Environmental Club, Film, Mole (Science), Photography, Jr. ROTC, Robotics, Tech Club, and an Ultimate Frisbee Club.