Marjolein Kriek

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Marjolein Kriek (born 22 November 1973)[1] is a Dutch clinical geneticist at the Leiden University Medical Center. In 2008, at age 34, she became the first woman and probably the first European to have her total DNA genome sequenced.[2][3][4][5]

Statue for Marjolein Kriek, Nijmegen, the Netherlands. Detail of the computer print:
Statue for Marjolein Kriek by Bas van Vlijmen (detail), Toernooiveld, Nijmegen, the Netherlands.jpg

Sequencing project[edit]

Leiden University announced the completion of the nine-month-long[4] sequencing of Dr. Kriek's genome on 26 May 2008,[3][5] though the results of the study were published later. The study was initiated by Gert-Jan van Ommen of the LUMC team and director of the Center for Medical Systems Biology (CMSB), to gain insight in X-chromosome variability. The data set contained significant redundancy, as each base pair was sampled an average of seven to eight times.[3][5] At the time Dr. Kriek was one of five or six people to have their entire genome sequenced, the others being James D. Watson, Craig Venter, two Yoruba-African men[2][3] and possibly Dan Stoicescu of Switzerland.[6]

Career and research interests[edit]

Dr. Kriek was born in Leiden and obtained her doctorate in Biomedical Science at Leiden University in 2002. Her graduate studies included mutation screening in the mentally retarded. Dr. Kriek's subsequent research interests similarly focussed on the diagnosis and clinical significance of genomic imbalances and micro rearrangements as the causes of developmental delay, mental retardation and congenital syndromes.[1]

See also[edit]


  1. ^ a b Online curriculum vitae, Leiden University
  2. ^ a b Coats, Christopher (December 27, 2009). "Dr. Marjolein Kriek, First Woman to Have Her DNA Sequence Determined". Retrieved 3 January 2012. 
  3. ^ a b c d "First Female DNA Sequenced". ScienceDaily. 26 May 2008. 
  4. ^ a b "Dutch Doctor is first woman to have DNA mapped". Mina. 1 June 2008. Retrieved 3 January 2012. 
  5. ^ a b c Davies, Kevin (2010). The $1,000 Genome: The Revolution in DNA Sequencing and the New Era of Personalized Medicine (1st ed.). Free Press. pp. 212–213. ISBN 1-4165-6959-6. 
  6. ^ Harmon, Amy (2008-03-04). "Gene Map Becomes a Luxury Item". The New York Times. Retrieved 2010-02-24.