In April 2011, Vandelli joined the cast of semi-reality television programme Made in Chelsea for the first series. He is currently the only male cast member to appear in all series of the show. On 16 January 2016, it was announced that he would be competing in the third series of The Jump. He withdrew from the show on 9 February due to injury. In 2017, he appeared in a Made in Chelsea spin-off entitled Mark-Francis' Big Night Out.
Vandelli is the founder and principal designer of an eponymous menswear brand based in London's Mayfair.
Vandelli was educated at St Paul's School, London, and read for a degree in Art History at University College London. He is gay. Vandelli is the only son of Marzio Vandelli, an Italian businessman who once owned a tile factory, and Diane Casserley Vandelli. It has been claimed that he is of Russian aristocratic or imperial descent through his mother, but she is of middle-class Anglo-Irish descent. 
|2011–||Made in Chelsea||Himself||Cast member|
|2016||The Jump||Series 3 - Withdrew|
|2017||Mark-Francis' Big Night Out|
- Alan Carr: Chatty Man – (4 May 2012)
- Celebrity Juice – (17 November 2013)
- Virtually Famous – (13 April 2015, 22 March 2016)
- "The Jump lineup confirmed as 12 famous faces prepare to hit the slopes". Channel 4 (Press release). 16 January 2016. Retrieved 21 December 2017.
- "Made in Chelsea star Mark-Francis Vandelli leaves The Jump". BBC News. 9 February 2016. Retrieved 21 December 2017.
- "Made In Chelsea's Mark-Francis Vandelli shares a romantic kiss with mystery man". The Daily Mail. 27 May 2014. Retrieved 10 December 2017.
- "Mark-Francis Vandelli net worth". Spear's Magazine. 21 December 2017. Retrieved 21 December 2017.
- "England and Wales Birth Registration Index, 1837-2008". Family Search. Retrieved 10 December 2017.
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