Mark Josephson

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Mark Josephson
BornJanuary 27, 1943
DiedJanuary 11, 2017
CitizenshipUnited States
Alma materTrinity College, Columbia University College of Physicians and Surgeons
Known forClinical Cardiac Electrophysiology: Techniques and Interpretations authorship
Scientific career
FieldsCardiac electrophysiology
InstitutionsBeth Israel Deaconess Medical Center, Harvard Medical School

Mark E. Josephson (1943-2017) was an American cardiologist and writer, who was in the 1970s one of the American pioneers of the medical cardiology subspecialty of cardiac electrophysiology. His book titled Clinical Cardiac Electrophysiology: Techniques and Interpretations is widely acknowledged as the definitive treatment of the discipline. He was the Herman Dana Professor of Medicine at Harvard Medical School and the director of the Harvard-Thorndike Electrophysiology Institute and Arrhythmia Service.[1] He was also until 2016 the chief of cardiology at Harvard University's Beth Israel Deaconess Medical Center in Boston.[2]


Josephson was a graduate of Trinity College[3] and subsequently went to medical school at Columbia University College of Physicians and Surgeons. He completed his residency training in Internal Medicine at Mount Sinai Hospital in New York City and his fellowship training in cardiology at the Perelman School of Medicine at the University of Pennsylvania.[4]

After spending two years as a research associate with Anthony Damato at the Staten Island Public Health Service Hospital, he published articles on the electrophysiologic basis and anatomic location of AV nodal reentry and map-guided subendocardial resection to cure ventricular tachycardia, a procedure Time dubbed "the Pennsylvania Peel" in honor of the Penn cardiology department's surgical innovation.[4] Josephson's work helped to transform electrophysiology from a research field to a powerful clinical discipline for treating patients.[5]

Josephson has published over 400 original journal articles and 200 book chapters and reviews and is the author of the textbook of clinical cardiac electrophysiology, Clinical Cardiac Electrophysiology: Techniques and Interpretations.[4] First published in 1979, the book has run to five editions.

Josephson worked closely over the years with European cardiac electrophysiology pioneer Hein Wellens, chief of cardiology emeritus at the University of Limburg in Maastricht, Netherlands. For over 30 years, they coached together at high-yield "How to Approach Complex Arrhythmias" course for cardiologists [6] and EP fellows.[7] In the 2000s, they initiated an advanced course "Intracardiac Unknowns" which was attended by almost all electrophysiology trainees in the USA for over 10 years.


Throughout his career Josephson won numerous awards. This includes the Career Achievement Award from the University of California San Francisco Medical School as well as the University Medal for Excellence from Columbia University as well as the Distinguished Teacher Award. He has been given the Pioneer Award in Cardiac Pacing and Electrophysiology from the Heart Rhythm Society. He also received the American Heart Association's Paul Dudley White Award and the Eugene Braunwald Academic Mentorship Award.[8][9][10]


Josephson and his wife, Joan, married in 1967 and remained married until her death in June 2016. They had two children. He died on January, 11 2017 from cancer.[11]


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  2. ^ Search - Beth Israel Deaconess Medical Center
  3. ^ Archived from the original on 2015-10-18. Missing or empty |title= (help)
  4. ^ a b c Marchlinski, Francis. "A Biography of Mark E. Josephson, M.D." Heart Rhythm Society Online. Internet, Archived 2009-07-19 at the Wayback Machine[Positional parameters ignored], 2010.
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  7. ^ "Archived copy" (PDF). Archived from the original (PDF) on 2013-12-03. Retrieved 2013-12-03.CS1 maint: archived copy as title (link)
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  11. ^ Retrieved 29 October 2017. Missing or empty |title= (help)