|Date of birth||9 September 1987|
|Place of birth||Cape Town, South Africa|
|Height||1.87 m (6 ft 1 1⁄2 in)|
|Playing position||Left winger|
|Old Mutual Academy|
|2013||Mpumalanga Black Aces||0||(0)|
|2016–2017||Ajax Cape Town||23||(3)|
|* Senior club appearances and goals counted for the domestic league only and correct as of 12:07, 22 October 2018 (UTC)|
Mayambela began his professional career with Bloemfontein Celtic in 2007 after joining from the Old Mutual Academy. He made his debut for the club against Ajax Cape Town during the 2007–08 Absa Premiership season. During his time at the club he became a fan favourite and earned the nickname "the Professor", ultimately making 50 appearances before joining Orlando Pirates in 2010.
Mayambela completed a transfer to Orlando Pirates on 27 July 2010, with Bennett Chenene joining Celtic as part of the deal. He struggled in Soweto, though, and by January 2013 had only started two matches in his three years with Pirates. He was linked with a move to Chippa United during the same month but the deal collapsed after he refused to sign a three-year contract, preferring to join on a six-month deal instead.
He made only one substitute appearance during the 2012–13 Premier Soccer League season following which Orlando Pirates elected to release him. During his time at the club, Orlando Pirates lifted two PSL titles, two MTN 8 titles, and one each in the Nedbank Cup and Telkom Cups. Following his release, Mayambela was linked with a move to an unnamed Turkish club and also trained with Moroka Swallows before signing a one-year deal with Mpumalanga Black Aces.
Mayambela officially joined Mpumalanga Black Aces in August 2013. His time at the club was short-lived, however, as he departed by mutual consent in October after he and teammate Mkhanyiseli Siwahla were alleged to have arrived at training under the influence of alcohol. Both players were asked to undergo alcohol tests at a clinic, but they refused and were suspended pending a disciplinary hearing. Mayambela and Siwahla then failed to attend at the hearing and were subsequently released from their contracts.
Mayambela later denied claims that he was drunk at training and stated that he left Aces because he was unhappy at the club. He failed to play in a single league match for the club and made his only appearance as a substitute in a Telkom Knockout game against former team Orlando Pirates.
Following his release from Black Aces, Mayambela trialled with Swedish side Djurgården who elected to sign him on a three-year deal. He made his debut for the club in the Swedish Cup on 9 March 2014 in a 2–0 win over Assyriska and made 15 league appearances in total, scoring once. His contract was terminated by mutual agreement in January 2015 after he had indicated that he wanted to return to South Africa, and he later revealed that his battles with injury and time on the bench had contributed to his decision.
Having once again become a free-agent, Mayambela signed for National First Division side Royal Eagles on a four-month deal in February 2015. He departed at the end of the season having made four appearances.
Following the expiration of his contract with Royal Eagles, Mayambela returned to the PSL when he signed a season-long deal with Port Elizabeth-based side Chippa United. Just six months into his contract, however, the club agreed to release Mayambela in order to allow him to join SuperSport United, with SuperSport agreeing to buy out the remainder of his contract. He made 10 appearances and scored twice during his time with the club.
Mayambela officially joined SuperSport United on 15 January 2016 and signed a three-and-a-half year contract with the club. Having been signed by Gordon Igesund, he struggled under new club-manager Stuart Baxter and made just four appearances for the club before once again being released. Baxter later stated that Mayambela had fallen short of the club's standards both on and off of the pitch.
Ajax Cape Town
Return to Chippa United
Mayambela was released by Ajax after one season following which he re-signed for Chippa United in July 2017. He scored his first goals since his return to the club on 4 February 2018, netting his first professional brace in a 3–3 draw with Platinum Stars. The following season, he was named captain of the side.
- Orlando Pirates
- Premier Soccer League: 2010–11; 2011–12
- MTN 8: 2010; 2011
- Telkom Knockout: 2011–12
- Nedbank Cup: 2010–11
- "Mayambela a Buccanneer". Orlando Pirates Football Club. 27 July 2010. Retrieved 13 September 2017.
- "Mayambela Returning To Siwelele?". Soccer Laduma. 10 January 2015. Retrieved 13 September 2017.
- Fakude, Ernest (19 December 2016). "Ajax Cape Town midfielder Mark Mayambela explains emotional moments with Bloemfontein Celtic fans". Kick Off. Retrieved 13 September 2017.
- "Pirates sign Celtic's Mayambela". Sport 24. 24 July 2010. Retrieved 25 November 2013.
- "Mark Mayambela and Bennett Chenene in swap deal". Kick Off. 27 July 2010. Retrieved 13 September 2017.
- Said, Nick (14 January 2013). "Mayambela 'upsets deal'". Sowetan Live. Retrieved 13 September 2017.
- Makhaya, Ernest (6 June 2013). "Orlando Pirates' Mark Mayambela could sign with an overseas club". Goal. Retrieved 13 September 2017.
- "Kaizer Chiefs join Orlando Pirates in second place for titles won". Kick Off. 23 April 2015. Retrieved 13 September 2017.
- "All 9 Of The MTN8 Champions". Soccer Laduma. 12 August 2017. Retrieved 13 September 2017.
- "Pirates win Telkom Knockout Cup". Sport 24. Retrieved 13 September 2017.
- "List of past Nedbank Cup winners". ENCA. 25 May 2016. Retrieved 13 September 2017.
- "Mayambela Running Out Of Time". Soccer Laduma. 2 August 2013. Retrieved 13 September 2017.
- Makhaya, Ernest (10 August 2013). "Former Orlando Pirates' Mark Mayambela signs for MP Black Aces". Goal. Retrieved 13 September 2017.
- Makhaya, Ernest (31 October 2013). "Mpumalanga Black Aces show Mayambela and Siwahla the door". Goal. Retrieved 13 September 2017.
- "Mayambela Responds To Aces Claims". Soccer Laduma. 1 November 2013. Retrieved 25 November 2013.
- Adam, Lunga (1 November 2013). "Just Not Mayambela!". Soccer Laduma. Retrieved 25 November 2013.
- Klate, Chad; wa ka Mabasa, Tiwani (17 February 2014). "Three-year deal for Mark Mayambela at Djurgardens". Kick Off.
- "Mayambela Becomes Fan Favourite". Soccer Laduma. 10 March 2017. Retrieved 13 September 2017.
- Abrahamsson, Samuel (5 January 2015). "Duo försvinner från Djurgården". Afon Bladet. Retrieved 13 September 2017.(in Swedish)
- Kruger, Keegan (11 August 2015). "Mayambela: Why I Left Europe". Soccer Laduma. Retrieved 13 September 2017.
- Qina, Masebe (19 February 2015). "Mayambela Signs NFD Deal". Soccer Laduma. Retrieved 13 September 2017.
- Said, Nick (7 July 2015). "Mark Mayambela joins Chippa United". Times Live. Retrieved 13 September 2017.
- Fakude, Ernest (8 January 2016). "Mark Mayambela released by Chippa United to join SuperSport United". Kick Off. Retrieved 13 September 2017.
- Fakude, Ernest (14 January 2016). "SuperSport United pay up for Mark Mayambela". Kick Off. Retrieved 13 September 2017.
- Qina, Masebe (15 January 2016). "Mayambela Starting SSU Training". Soccer Laduma. Retrieved 13 September 2017.
- Qina, Masebe (20 April 2017). "Mayambela Released From SuperSport". Soccer Laduma. Retrieved 13 September 2017.
- Madlala, Robin-Duke (2 May 2016). "Stuart Baxter explains Mark Mayambela exit". Kick Off. Retrieved 13 September 2017.
- Zuma, Makhosonke (12 September 2016). "Ajax Cape Town's Mark Mayambela relishing Orlando Pirates reunion". Kick Off. Retrieved 13 September 2017.
- "Two Former Pirates Teammates To Link Up At City?". Soccer Laduma. 21 June 2017. Retrieved 13 September 2017.
- "Chippa United sign Mark Mayambela". The Citizen. 18 July 2017. Retrieved 13 September 2017.
- Martin, Paul (4 February 2018). "Six-goal thriller, but Chippa and Platinum Stars share points". Independent Online. Retrieved 6 April 2018.
- "Chippa United's Mark Mayambela picks top 10 moments from 10 years of professional football". Kick Off. 13 February 2018. Retrieved 6 April 2018.
- "Mayambela appointed new Chippa United captain". Diski Fans. 3 August 2018. Retrieved 10 October 2018.
- Ngidi, Njabulo (8 April 2015). "Mihlali Mayambela – a star in the making". The Citizen. Retrieved 13 September 2017.