Sir Mark Pepys
Mark Brian Pepys
|Institutions||University College London|
|Thesis||Role of complement in induction of the allergic response (1973)|
Pepys finished his early education at the University of Cambridge, and then qualified as a medical doctor at University College London Medical School. He then returned to Cambridge where he was awarded a PhD in Immunology in 1973.
Awards and honours
Pepys won the GlaxoSmithKline Prize in 2007 "for his excellent work as a clinical scientist who has identified specific proteins as new therapeutic targets and developed novel drugs with potential use in amyloidosis, Alzheimer's disease and cardiovascular disease". In 1998, Pepys was elected a Fellow of the Royal Society (FRS). His nomination reads:
|“||Pepys has made seminal contributions in three areas: complement and immune response, the pentraxin proteins, and amyloidosis, and is a leading authority on these subjects in the UK and internationally. He discovered the role of complement in induction of antibody production and antigen localisation to germinal centres. He has pioneered work on the structure, function and clinical applications of the pentraxins, C-reactive protein (CRP) and serum amyloid P component (SAP), and identified most of the known members of this valuable aid to patient management. He discovered the capacity of SAP for calcium-dependent binding, which underlies its universal deposition in amyloid, described its interaction with DNA in-vivo and in-vitro, and its ability to solubilise chromatin, and identified SAP as a normal tissue protein. He introduced radiolabelled SAP as a diagnostic in-vivo tracer for amyloid, which has revolutionised knowledge of the natural history of amyloidosis and its response to treatment. He has discovered that variants of lysozyme can form amyloid and identified the first mutations in the human lysozyme gene, as well as novel amyloidogenic variants of apolipoprotein AI and transthyretin.||”|
In 1999 he became director of the University College London Centre for Amyloidosis and Acute Phase Proteins.
- "EC/1998/26: Pepys, Mark Brian". London: The Royal Society. Archived from the original on 2014-09-30.
- "Iris View Profile". iris.ucl.ac.uk. Retrieved 2017-12-13.
- Booth, D. R.; Sunde, M; Bellotti, V; Robinson, C. V.; Hutchinson, W. L.; Fraser, P. E.; Hawkins, P. N.; Dobson, C. M.; Radford, S. E.; Blake, C. C.; Pepys, M. B. (1997). "Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis". Nature. 385 (6619): 787–93. doi:10.1038/385787a0. PMID 9039909.
- "The Royal Society GlaxoSmithKline Prize and Lecture (1976) (2002)". royalsociety.org. Archived from the original on 9 June 2008. Retrieved 2009-04-03.
- "Mark Pepys". royalsociety.org. Retrieved 2017-12-13.
- "No. 60009". The London Gazette (Supplement). 31 December 2011. p. 1.
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