Mark Siegler

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Mark Siegler
Mark Siegler - June 2015 Headshot.jpg
Born Mark Siegler
Nationality United States
Fields Medicine, medical ethics
Institutions University of Chicago
Alma mater University of Chicago (M.D.)
Princeton University (B.A.)

Mark Siegler (born June 20, 1941) is an American physician who specializes in internal medicine. He is the Lindy Bergman Distinguished Service Professor of Medicine and Surgery at the University of Chicago. One of the nation's leading medical ethicists,[1] he is the Founding Director of the University of Chicago's MacLean Center for Clinical Medical Ethics. Siegler has practiced and taught internal medicine at the University of Chicago for more than 53 years.

In 2011, the Matthew and Carolyn Bucksbaum Family Foundation presented an endowment to the University of Chicago to create the Bucksbaum Institute for Clinical Excellence. Siegler was appointed the Executive Director of the Institute. The mission of the Bucksbaum Institute is to improve patient care, to strengthen the doctor-patient relationship, and to enhance communication and decision-making between patients and physicians through research and education programs for medical students, junior faculty and master clinicians.

Siegler has published more than 215 journal articles, 65 book chapters and five books. His textbook, co-authored with Al Jonsen and William Winslade, Clinical Ethics: A Practical Approach to Ethical Decisions in Clinical Medicine, 8th Edition (2015),[2] has been translated into eight languages and is widely used by physicians and health professionals around the world.

Clinical medical ethics[edit]

In the 1970s, Mark Siegler helped launch the field of clinical medical ethics in the Biological Sciences Division of the University of Chicago. Clinical medical ethics is a practical, applied field that aims to improve patient care and outcomes. Clinical ethics helps patients, families and professionals reach good clinical decisions based on medical facts, patient preferences, and ethical considerations. The MacLean Center for Clinical Medical Ethics at the University of Chicago has played a major role in creating, establishing, and expanding the field of clinical medical ethics. In 1983, the MacLean Center was established after receiving a naming gift from Dorothy Jean MacLean and the MacLean family. The MacLean Center was inspired by the clinical models of William Osler and Alvan Feinstein. The Center has helped to change and expand American medical ethics by helping to bring ethics to the bedside. During the past 40 years, clinical ethics has emerged as one of the core components of the American bioethics movement. Today, virtually every major hospital has an ethics committee or ethics consultation service available to help resolve most ethical problems; scholarly clinical ethics papers are published widely in both bioethics and medical journals; medical organizations now have ethics committees and codes of ethics; newspapers cover important clinical ethics issues; and most importantly, clinical ethics deliberations and analyses have become part of the clinical conversation that occurs routinely in doctors’ offices and hospitals across the country.

Selected awards and honors[edit]

1996 - Chirone Prize, Italian Medical Association and the University of Bolognia

2006 - Served on the board of trustees at Princeton University

2007 - Distinguished Service Award, Medical and Biological Sciences Alumni Association

2010 - Received Lifetime Achievement Award from the American Society of Bioethics and Humanities

2011 - Named Executive Director of the Bucksbaum Institute for Clinical Excellence at the University of Chicago

2013 - On September 30, celebrated 50th Anniversary at the University of Chicago; Presented White Coat Talk to the incoming first year medical students at Pritzker School of Medicine, University of Chicago; MacLean Center received the Cornerstone Award from the American Society of Bioethics and Humanities

2014 - Chosen to present the 25th Annual Coggeshall Lecture on medical ethics, Biological Science Division, University of Chicago

2015 - The John Conley Foundation Award for Outstanding Contributions to Clinical Ethics.

2015 - Awarded Mastership by the American College of Physicians[3]

Selected publications[edit]

  • Siegler M. Pascal's wager and the hanging of crepe. N Engl J Med 1975; 293:853-7.
  • Siegler M. Clinical ethics and clinical medicine. Arch Intern Med 1979; 139:914-5.
  • Siegler M. Searching for moral certainty in medicine: A proposal for a new model of the doctor-patient encounter. Bull NY Acad Med 1981; 57:56-69.
  • Siegler M. Decision-making strategy for clinical ethical problems in medicine. Arch Intern Med 1982; 142:2178-9.
  • Siegler M. Confidentiality in medicine: A decrepit concept. N Engl J Med 1982; 307:1518-1521.
  • Siegler M. The progression of medicine: From physician paternalism to patient autonomy to bureaucratic parsimony. Arch Intern Med 1985; 145:713-15.
  • La Puma J, Stocking CB, Silverstein MD, DiMartini A, Siegler M. An ethics consultation service in a teaching hospital-utilization and evaluation. JAMA 1988; 260:808-811.
  • Singer PA, Siegler M, Lantos JD, Emond JC, Whitington PF, Thistlethwaite JR, Broelsch CE. Ethics of liver transplantation with living donors. N Engl J Med 1989; 321:620-622.
  • Siegler M, Pellegrino ED, Singer PA. Clinical medical ethics: The first decade. J Clin Ethics 1990;1:5-9.
  • Singer PA, Siegler M. Euthanasia: A critique. N Engl J Med 1990;322:1881-3.
  • Kodish E, Lantos JD, Kohrman A, Johnson FL, Siegler M. Bone marrow transplantation in sickle cell disease: The trade-off between early mortality and quality of life. Clinical Research 1990; 38:694-700. [This paper was awarded an honorable mention in the Nellie Westerman prize competition.]
  • Siegler M. A medicine of strangers or a medicine of intimates: The two legacies of Karen Ann Quinlan. Second Opinion. 1992; 17:64-69.
  • Siegler M. Falling off the pedestal: What is happening to the traditional doctor-patient relationship? Mayo Clinic Proceedings. 1993; 68:1-7.
  • Ratain M, Mick R, Schilsky R, Siegler M. Statistical and ethical issues in the design and conduct of Phase I and II Clinical trials of new anticancer agents. J National Cancer Institute. 1993; 85:1637-43.
  • Daugherty C, Ratain MJ, Siegler M. Editorial. Pushing the envelope: Informed consent in Phase I trials. Ann Onc 1995; 6:321-323.
  • Moss AH, Oppenheimer EA, Casey P, Cazzolli PA, Roos R, Stocking CB, Siegler M. Patients with Amyotrophic Lateral Sclerosis receiving long-term mechanical ventilation: Advance Care Planning and Outcomes. Chest 1996; 110:249-55.
  • Siegler M. The contributions of clinical ethics to patient care. Forum: Trends in Experimental and Clinical Medicine 1997; 7: 244-253.
  • Siegler M. Ethical Issues in Innovative Surgery: Should we attempt a cadaveric hand transplantation in a human subject? Transplantation Proceedings 1998; 30: 2779-2782.
  • Helft P, Siegler M, Lantos J. The rise and fall of the futility movement. NEJM 2000; 343(4):293-296.
  • Cronin D, Millis M, Siegler, M. Transplantation of liver grafts from living donors into adults: Too Much, Too Soon. NEJM 2001; 344(21):1633-1638.
  • Siegler M, Simmerling M, Siegler J, Cronin DC. Recipient deaths during donor surgery: A new ethical problem in living donor liver transplantation. Liver Transplantation 2006; 12 (3): 358-360.
  • Dugdale L, Siegler M, Rubin D, Medical Professionalism and the Doctor-Patient Relationship. Perspectives in Biology and Medicine 2008; 51:547-553.
  • Pomfret E, Lodge J, Villamil F, Siegler M. 2010 Consensus Conference on Liver Transplantation for HCC: Should we use living donor grats for patients with hepatocellular carcinoma (HCC)? Ethical Considerations. Liver Transplantation. 2011:17: S128–S132.
  • Frilling A, Modlin IM, Kidd M, Russell C, Breitenstein S, Salem R, Kwekkeboom D, Lau W, Klersy C, Vilgrain V, Davidson B, Siegler M, Caplin M, Solcia E, Schilsky R. Recommendations for management of patients with neuroendocrine liver metastases. Lancet Oncology. January 2014;15(1):e8-e21.
  • Miller M, Siegler M, Angelos P. Ethical Issues in Surgical Innovation. World Journal of Surgery. April 2014.


  1. ^ Dirk Johnson (September 22, 2011). "A $42 Million Gift Aims at Improving Bedside Manner". The New York Times. 
  2. ^ Fine RL (2010). "Clinical Ethics: A Practical Approach to Ethical Decisions in Clinical Medicine" JAMA. 296(15):1905-1906. doi:10.1001/jama.296.15.1905-b
  3. ^ url=

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