Mark Siegler

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Mark Siegler
Born Mark Siegler
Nationality United States
Alma mater University of Chicago (M.D.)
Princeton University (B.A.)
Scientific career
Fields Medicine, medical ethics
Institutions University of Chicago

Mark Siegler (born June 20, 1941) is an American physician who specializes in internal medicine. He is the Lindy Bergman Distinguished Service Professor of Medicine and Surgery at the University of Chicago. One of the nation's leading medical ethicists,[1] he is the Founding Director of the University of Chicago's MacLean Center for Clinical Medical Ethics. Siegler has practiced and taught internal medicine at the University of Chicago for more than 50 years.

In 2011, the Matthew and Carolyn Bucksbaum Family Foundation presented an endowment to the University of Chicago to create the Bucksbaum Institute for Clinical Excellence. Siegler was appointed the Executive Director of the Institute. The mission of the Bucksbaum Institute is to improve patient care, to strengthen the doctor-patient relationship, and to enhance communication and decision-making between patients and physicians through research and education programs for medical students, junior faculty and master clinicians.

Siegler has published more than 215 journal articles, 65 book chapters and five books. His textbook, co-authored with Al Jonsen and William Winslade, Clinical Ethics: A Practical Approach to Ethical Decisions in Clinical Medicine, 8th Edition (2015),[2] has been translated into eight languages and is widely used by physicians and health professionals around the world.

Clinical medical ethics[edit]

Clinical medical ethics is a practical, applied field that aims to improve patient care and outcomes. In the 1970s, Mark Siegler helped launch the field of clinical medical ethics in the Biological Sciences Division of the University of Chicago. Clinical ethics helps patients, families, and professionals reach good clinical decisions based on medical facts, patient preferences, and ethical considerations.

The MacLean Center for Clinical Medical Ethics at the University of Chicago has played a major role in creating, establishing, and expanding the field of clinical medical ethics. In 1983, the MacLean Center was established after receiving a naming gift from Dorothy Jean MacLean and the MacLean family. Inspired by the clinical models of William Osler and Alvan Feinstein, the MacLean Center has helped to change and expand American medical ethics by helping to bring ethics to the bedside. In the words of the Johns Hopkins Berman Institute of Bioethics, the MacLean Center has "populated the field of clinical ethics in perpetuity."

During the past 40 years, clinical ethics has emerged as one of the core components of the American bioethics movement. Today, virtually every major hospital has an ethics committee or ethics consultation service available to help resolve most ethical problems; scholarly clinical ethics papers are published widely in both bioethics and medical journals; medical organizations now have ethics committees and codes of ethics; newspapers cover important clinical ethics issues; and most importantly, clinical ethics has become an integral part of physicians' routine care for their patients.

Selected awards and honors[edit]

1996 - Chirone Prize, Italian Medical Association and the University of Bologna

2006 - 2010 Served on the Board of Trustees at Princeton University

2007 - Distinguished Service Award, Medical and Biological Sciences Alumni Association, University of Chicago

2010 - Received Lifetime Achievement Award from the American Society of Bioethics and Humanities (ASBH)

2011 - Named Executive Director of the Bucksbaum Institute for Clinical Excellence at the University of Chicago[3]

2013 - The MacLean Center received the Cornerstone Award from the American Society of Bioethics and Humanities

2014 - Chosen to present the 25th Annual Coggeshall Lecture on medical ethics, Biological Science Division, University of Chicago

2015 - The John Conley Foundation Award for Outstanding Contributions to Clinical Ethics.

2015 - Awarded Mastership by the American College of Physicians[4]

2016 - Johns Hopkins Berman Institute Harvey M. Meyerhoff Leadership in Bioethics Award

Selected publications[edit]

  • Siegler M. Pascal's wager and the hanging of crepe. N Engl J Med 1975; 293:853-7.
  • Siegler M. Critical illness: The limits of autonomy. Hast Cent Rep. 1977; 7:12-15.
  • Siegler M. A legacy of Osler: Teaching clinical ethics at the bedside. JAMA. 1978;239:951-6.
  • Siegler M. Clinical ethics and clinical medicine. Arch Intern Med 1979; 139:914-5.
  • Siegler M. Searching for moral certainty in medicine: A proposal for a new model of the doctor-patient encounter. Bull NY Acad Med 1981; 57:56-69.
  • Siegler M. The doctor-patient encounter and its relationship to theories of health and disease. In: Caplan AL, Engelhardt HT Jr, McCartney JJ, eds. Concepts of Health and Disease: Interdisciplinary Perspectives. Reading, Massachusetts: Addison-Wesley, 1981: 627-44.
  • Siegler M, Goldblatt AD. Clinical Intuition: A procedure for balancing the rights of patients and the responsibilities of physicians. In: Spicker SF, Healey JM, Engelhardt HT Jr. eds. The Law-Medicine Relation: A Philosophical Exploration. Boston and Dordrecht, Holland: D. Reidel, 1981: 5-31.
  • Siegler M. Decision-making strategy for clinical ethical problems in medicine. Arch Intern Med 1982; 142:2178-9.
  • Siegler M. The physician-patient accommodation: a central event in clinical medicine. Arch Intern Med. 1982; 143:1899-1902.
  • Siegler M. Confidentiality in medicine: A decrepit concept. N Engl J Med 1982; 307:1518-1521.
  • Siegler M, Wikler D. Brain death and live birth. JAMA. 1982; 248:1101-2.
  • Siegler M. Medical consultations in the context of the physician-patient relationship. In: Agich, GJ, ed. Responsibility in Health Care. Boston and Dordrecht, Holland: D. Reidel, 1982; 141-62.
  • Childress JF, Siegler M. Metaphors and models of doctor-patient relationships: Their implications for autonomy. Theoret Med. 1984; 5:17-30.
  • Siegler M. The progression of medicine: From physician paternalism to patient autonomy to bureaucratic parsimony. Arch Intern Med 1985; 145:713-15.
  • Culver C, Clouser KD, Gert B, Siegler M, et al. Basic curricular goals in medical ethics: The DeCamp conference on the teaching of medical ethics. NEJM. 1985; 312:253-56.
  • La Puma J, Stocking CB, Silverstein MD, DiMartini A, Siegler M. An ethics consultation service in a teaching hospital-utilization and evaluation. JAMA 1988; 260:808-811.
  • Lane LW (Roberts), Siegler M, Miles SH, Cassel CK, Singer PA. Fellowship training programs in clinical ethics. Soc Gen Intern Med Newsletter. 1988; 3:4-5.
  • Singer PA, Siegler M, Lantos JD, Emond JC, Whitington PF, Thistlethwaite JR, Broelsch CE. Ethics of liver transplantation with living donors. N Engl J Med 1989; 321:620-622.
  • Lantos JD, Siegler M, Cuttler L. Ethical issues in growth hormone therapy. JAMA. 1989; 261:1020-4.
  • Arnow P, Pottenger L, Stocking C, Siegler M. DeLeeuw H. Orthopedic surgeons' attitudes and practices concerning the treatment of patients with human immunosuppressive virus infection. Public Health Reports. 1989; 104(2): 121-129.
  • Helft P, Siegler M, Lantos J. The rise and fall of the futility movement. NEJM. 2000; 343(4): 293-296.
  • Singer PA, Pellegrino ED, Siegler M. Ethics committees and consultants. J Clin Ethics. 1990 Winter;1(4):263-7.
  • Siegler M, Pellegrino ED, Singer PA. Clinical medical ethics: The first decade. J Clin Ethics 1990;1:5-9.
  • Pellegrino ED, Siegler M, Singer PA. Teaching clinical ethics. J Clin Ethics. 1990; 1:175-180.
  • Singer PA, Siegler M. Euthanasia: A critique. N Engl J Med 1990;322:1881-3.
  • Lane LW (Roberts), Lane G, Schiedermayer DL, Spiro JH, Siegler M. Caring for medical students as patients. Arch Intern Med. 1990; 150:2249-2253.
  • Kodish E, Lantos JD, Kohrman A, Johnson FL, Siegler M. Bone marrow transplantation in sickle cell disease: The trade-off between early mortality and quality of life. Clinical Research 1990; 38:694-700. [This paper was awarded an honorable mention in the Nellie Westerman prize competition.]
  • Pellegrino ED, Siegler M, Singer PA. Future directions in clinical ethics. J Clin Ethics. 1991 Spring;2(1):5-9.
  • Singer PA, Siegler M. Clinical ethics. In: W. Kelley, et al., eds. Textbook of Internal Medicine. Philadelphia; JB Lippincott Co., 1991;2:3-5.
  • Singer PA, Siegler M. Elective Use of life-sustaining treatments in internal medicine. In: Stollerman GH, ed. Advances in Internal Medicine. 1991; 57-79.
  • Siegler M. A medicine of strangers or a medicine of intimates: The two legacies of Karen Ann Quinlan. Second Opinion. 1992; 17:64-69.
  • Siegler M, Lantos JD. Ethical justification for living liver donation. Cambridge Quarterly of Healthcare Ethics. 1992; 4:320-325.
  • Siegler M. Falling off the pedestal: What is happening to the traditional doctor-patient relationship? Mayo Clinic Proceedings. 1993; 68:1-7.
  • Ratain M, Mick R, Schilsky R, Siegler M. Statistical and ethical issues in the design and conduct of Phase I and II Clinical trials of new anticancer agents. J National Cancer Institute. 1993; 85:1637-43.
  • Siegler M, Taylor RM. Intimacy and caring: The legacy of Karen Ann Quinlan. Trends in Health Care, Law, and Ethics. 1993; 8(1):28-30.
  • Daugherty C, Ratain MJ, Siegler M. Editorial. Pushing the envelope: Informed consent in Phase I trials. Ann Onc 1995; 6:321-323.
  • Moss AH, Oppenheimer EA, Casey P, Cazzolli PA, Roos R, Stocking CB, Siegler M. Patients with Amyotrophic Lateral Sclerosis receiving long-term mechanical ventilation: Advance Care Planning and Outcomes. Chest 1996; 110:249-55.
  • Singer PA, Siegler M. Clinical ethics in the practice of medicine. In: JB Wyngaarten, F Plum, and C Bennett, eds. Cecil Textbook of Medicine, 20th ed., WB Saunders Co.: Philadelphia, 1996; 4-6.
  • Roberts LW, Hardee JT, Franchini G, Sidley C, Siegler M. Medical students as patients: A pilot study of their health care needs, practices, and concerns. Academic Medicine 1996; 71(11): 1225-1232.
  • Roberts LW, McCarty T, Roberts BB, Morrison N, Belitz J, Berenson C, Siegler M. Clinical ethics teaching in psychiatric supervision. Academic Psychiatry 1996; 20(3): 172-184.
  • Roberts LW, McCarty T, Lyketsos C, Hardee JT, Jacobson J, Walker R, Hough P, Gramelspacher G. Stidley C, Arambula M, Heebink DM, Zornberg GL, Siegler M. What and how psychiatry residents at ten training programs wish to learn about ethics. Academic Psychiatry 1996; 127-139.
  • Siegler M. The contributions of clinical ethics to patient care. Forum: Trends in Experimental and Clinical Medicine 1997; 7: 244-253.
  • Ross LF, Siegler M. Five major themes in bioethics. Forum: Trends in Experimental and Clinical Medicine. 1997; 7.3 (Suppl.5): 8-17.
  • Daugherty CK, Siegler M, Ratain MJ, Zimmer G. Learning from our patients: One participants impact on clinical trial research and informed consent. Ann Internal Med. 1997; 126:892-7.
  • Siegler M. Ethical Issues in Innovative Surgery: Should we attempt a cadaveric hand transplantation in a human subject? Transplantation Proceedings 1998; 30: 2779-2782.
  • Helft P, Siegler M, Lantos J. The rise and fall of the futility movement. NEJM 2000; 343(4):293-296.
  • Cronin D, Millis M, Siegler, M. Transplantation of liver grafts from living donors into adults: Too Much, Too Soon. NEJM 2001; 344(21):1633-1638.
  • Siegler M. Training doctors for professionalism: Some lessons from teaching clinical medical ethics. Mt. Sinai Medical Journal. 2002; 69:404-409.
  • Siegler M, Simmerling M, Siegler J, Cronin DC. Recipient deaths during donor surgery: A new ethical problem in living donor liver transplantation. Liver Transplantation 2006; 12 (3): 358-360.
  • Torke AM, Alexander GC, Lantos J, Siegler M. The physician-surrogate relationship. Archives of Internal Medicine. June 2007;167:1117-1121.
  • Dugdale L, Siegler M, Rubin D, Medical Professionalism and the Doctor-Patient Relationship. Perspectives in Biology and Medicine 2008; 51:547-553.
  • Testa G, Angelos P, Crowley-Matoka M, Siegler M. Elective Surgical Patients as Living Organ Donors: A Clinical and Ethical Innovation. American Journal of Transplantation. 2009; 9:2400-2405.
  • Pomfret E, Lodge J, Villamil F, Siegler M. 2010 Consensus Conference on Liver Transplantation for HCC: Should we use living donor grats for patients with hepatocellular carcinoma (HCC)? Ethical Considerations. Liver Transplantation. 2011:17: S128–S132.
  • Frilling A, Modlin IM, Kidd M, Russell C, Breitenstein S, Salem R, Kwekkeboom D, Lau W, Klersy C, Vilgrain V, Davidson B, Siegler M, Caplin M, Solcia E, Schilsky R. Recommendations for management of patients with neuroendocrine liver metastases. Lancet Oncology. January 2014;15(1):e8-e21.
  • Miller M, Siegler M, Angelos P. Ethical Issues in Surgical Innovation. World Journal of Surgery. April 2014.


  1. ^ Dirk Johnson (September 22, 2011). "A $42 Million Gift Aims at Improving Bedside Manner". The New York Times. 
  2. ^ Fine RL (2010). "Clinical Ethics: A Practical Approach to Ethical Decisions in Clinical Medicine" JAMA. 296(15):1905-1906. doi:10.1001/jama.296.15.1905-b
  3. ^ Dirk Johnson (September 22, 2011). "A $42 Million Gift Aims at Improving Bedside Manner". The New York Times. 
  4. ^ url=

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