Born in Harrogate, West Riding of Yorkshire, Umbers was brought up in Wetherby and was educated at Malsis School before attending Sedbergh School. In 1995 he graduated from Oxford University with a degree in Latin and Greek Literature and Philosophy.
Umbers' first professional engagements were in 1997 in the BBC dramas The Student Prince and Berkeley Square . His theatre debut was the lead role in a production of The Pirates of Penzance which transferred to Regent's Park Open Air Theatre in London.
Trevor Nunn and John Caird cast Umbers in their multi-award-winning 1999 season at the Royal National Theatre, where he appeared in productions including The Merchant of Venice, which was later filmed for broadcast by the BBC. After playing Lord Sidney opposite Richard E. Grant in the BBC series The Scarlet Pimpernel , Umbers returned to the National to play Freddy in the acclaimed 2001 revival of My Fair Lady, later transferring to Theatre Royal Drury Lane.
In 2002 Umbers appeared alongside Chiwetel Ejiofor in The Vortex, Michael Grandage's inaugural production at the Donmar Warehouse, after which he was cast opposite Scarlett Johansson in A Good Woman. After playing opposite Anjelica Huston and Lauren Bacall in These Foolish Things  and John Malkovich in Colour Me Kubrick , he played the lead role of Perkin Warbeck in Channel 4's historical drama Princes in the Tower  and a further leading role in the mini-series Blackbeard, opposite Jessica Chastain.
In 2007, Umbers played the Gentleman Caller in The Glass Menagerie alongside Jessica Lange in the West End to critical acclaim. Later that year Steven Soderbergh cast Umbers as Roth in Che: Part Two. The following year, he starred in the second series of the BBC drama Mistresses and the BBC film of The Turn of the Screw, playing The Master opposite Michelle Dockery.
The Menier Chocolate Factory cast Umbers in their revival of Sweet Charity, the first production of the show to have only one leading man, with Umbers playing all the love-interest roles. The production transferred to the Theatre Royal Haymarket in 2010. Of Umbers' performance, Michael Coveney wrote in The Independent that "it's unusual to have such a level of performance in a musical...and it raises everyone else's game."
After appearing in the ITV drama Eternal Law, in 2011 Umbers played Frank Hunter in The Browning Version opposite Anna Chancellor at Chichester Festival Theatre. The play was performed in a double bill with David Hare's new play South Downs and transferred to the Harold Pinter Theatre in London in April 2012.
Umbers returned to the Menier Chocolate Factory in November 2012, to play the central role of Franklin Shepard in Maria Friedman's multi-award-winning revival of Stephen Sondheim's Merrily We Roll Along. The production transferred with its original cast to the Harold Pinter Theatre on 1 May 2013, receiving more 5 star reviews than any other production in West End history, along with the Critics' Circle Award for Best Musical, the Evening Standard Award for Best Musical and the Olivier Award for Best Musical revival. The production was filmed and subsequently screened in cinemas worldwide.
Between 2014 and 2016, Umbers played Wing Commander Nick Lucas in the ITV and PBS World War Two drama Home Fires. After playing the lead role of Georg in She Loves Me at the Menier Chocolate Factory in 2016, he played Robert Walsh in David Hare's Netflix series Collateral alongside Carey Mulligan.
In August 2017, he reprised his role as Franklin Shepard in Merrily We Roll Along for Huntington Theatre Company in Boston, again directed by Friedman. The Boston Globe described his performance as "simply extraordinary". HuffPost cited Stephen Sondheim as having said that Umbers was the best in the role that he had ever seen. Ben Brantley wrote in the New York Times: "For the first time in my experience, Frank is the beating, shattered heart of the show...a consequence Mr. Umbers’s startlingly sympathetic performance of a (usually unsympathetic) man to whom fame happens."
- IMDb, Mark Umbers
- Miles Kington article in The Independent 1998
- Michael Billington's Guardian review of The Pirates of Penzance, 2000
- Masterpiece Theater, The Merchant of Venice
- IMDb The Scarlet Pimpernel: A Good Name
- Variety review "My Fair Lady" 20 March 2001
- Washington Post review of A Good Woman 2006
- IMDb credits, These Foolish Things
- IMDb credits, Color Me Kubrick
- Austin Chronicle review, Color Me Kubrick
- Sydney Morning Herald interview with Mark Umbers, 2008
- Variety review of Blackbeard, 2006
- Financial Times review The Glass Menagerie 2007
- Review round-up The Glass Menagerie 2007
- Evening Standard review The Glass Menagerie 2007
- New York Times review The Glass Menagerie 2007
- IMDb credits, Che: Part Two
- BBC press release: Mistresses
- BBC press release: The Turn of the Screw, 2009
- Official London Theatre interview, 2010
- The Spectator review Sweet Charity 2009
- The Independent review Sweet Charity 2009
- The Independent review Sweet Charity 2010
- Daily Telegraph review The Browning Version 2012
- The Arts Desk review The Browning Version 2012
- The Guardian review Merrily We Roll Along 2012
- The Arts Desk review Merrily We Roll Along 2012
- New York Times review Merrily We Roll Along 2013
- Daily Telegraph review Merrily We Roll Along 2013
- The Independent review Merrily We Roll Along 2013
- Daily Express review Merrily We Roll Along 2013
- Official London Theatre, 2013
- New York Times article by Ben Brantley, October 2013
- The Observer review of She Loves Me, 2016
- Digital Spy, 2018
- Boston Globe review of Merrily We Roll Along, September 2017
- HuffPost interview with Mark Umbers, August 2017
- Ben Brantley's New York Times review of Merrily We Roll Along, October 2017