Hampton has released two self-produced CD-Rs, Book One (2006) and Book Two (2007), containing a mix of original and traditional songs. In 2008 she released My Mother's Children, her first commercially available album, on Navigator Records. The album has been described as "a sparse collection of her own songs, which recline with shimmering sensuality in various shady cloaks of weirdness" and as "songs of unnerving delicacy, elemental and acoustic simplicity...potent and enchanting".
In addition, Hampton contributed vocals to Rough Music, a 2005 album by Eliza Carthy, and sang on Blow It Up, Burn It Down, Kick It 'Til It Bleeds, a 2006 album by Stereolab side project Imitation Electric Piano.
In June 2009 she toured the UK alongside American singer Diane Cluck.
In June 2011 she toured the UK with her band Mary Hampton Cotillion (made up of musicians Seth Bennett, Jo Burke, Alice Eldridge and Alistair Strachan). Dates included a show at Blaise Castle in Bristol and an inaugural performance in the new rooftop garden at Queen Elizabeth Hall on London's South Bank.
In July 2011, Rough Trade put out a limited edition 7" of the songs "Honey in the Rock" and "Hoax and Benison" from her album "Folly".
- Colin Irwin, Daily Telegraph, 26 April 2008, p.10.
- David Stubbs, Uncut, August 2008.
- Rough Music Archived 2008-10-01 at the Wayback Machine.. Topic Records website, retrieved 7 October 2008.
- Peter Paphides, Times, 10 November 2006, p.19.
- Jeanette Leech & Richard S Jones, Shindig!, Nov-Dec 2008, p.80.