Mary Lorson was born and raised in the suburbs of New York City. She formed Madder Rose with Billy Coté in 1991 in a Greenwich Village apartment. Lorson left the band in 1997 and founded the group Saint Low with bassist Stahl Caso, violinist Joe Myer, pianist Michael Stark, vocalist Jennie Stearns, and drummer Zaun Marshburn. Lorson and Coté toured with Tanya Donelly in 1996-7.
Lorson's tenth full-length disc "BurnBabyBurn" was released in 2011. Lorson and Coté created the original score for "What Remains: The Life and Art of Sally Mann" for Steven Cantor and HBO. She and Coté have a son, Roman. A breast cancer survivor and high school English teacher, Lorson is the author of "Freak Baby and the Kill Thought," an original screenplay about the life of Eva Tanguay. She is currently developing a television project titled "Old School," and scoring the independent web-series "The Chanticleer." As of 2015 Mary Lorson is working on setting a chapter of James Joyce's Finnegans Wake to music, for the Waywords and Meansigns project.