In 1956 three 250F T2 cars first appeared for the works drivers. Developed by Giulio Alfieri using lighter steel tubes they sported a slimmer, stiffer body and sometimes the new 315 bhp (235 kW) V12 engine, although it offered little or no real advantage over the older straight 6. It was later developed into the 3 litre V12 that won two races powering the Cooper T81 and T86 from 1966 to 1969, the final "Tipo 10" variant of the engine having three valves and two spark plugs per cylinder.
In 1957Juan Manuel Fangio drove to four more championship victories, including his legendary final win at German Grand Prix at the Nürburgring (Aug. 4, 1957), where he overcame a 48-second deficit in 22 laps, passing the race leader, Mike Hawthorn, on the final lap to take the win. In doing so he broke the lap record at the Nürburgring, 10 times.
By the 1958 season, the 250F was totally outclassed by the new rear engined F1 cars. However, the car remained a favourite with the privateers, including Maria Teresa de Filippis, and was used by back markers through the 1960 F1 season, the last for the 2.5 litre formula.
In total, the 250F competed in 46 Formula One championship races with 277 entries, leading to eight wins. Success was not limited to World Championship events with 250F drivers winning many non-championship races around the world.
Stirling Moss later said that the 250F was the best front-engined F1 car he drove.