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Mastermind, in comics, may refer to:
- Mastermind (Jason Wyngarde), the first Marvel Comics supervillain to use the title.
- Mastermind (computer), an enemy of Captain Britain
- Master Mind Excello, a Golden Age superhero
- Amadeus Cho, who also operates under the name "Mastermind Excello"
- Master Mind (comic strip), a British comic strip
- Mastermind (DC Comics), an enemy of the Challengers of the Unknown.
| This article includes a list of related items that share the same name (or similar names).
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