His work has been exhibited at galleries and museums including Whitney Museum of American Art and the Hermitage Museum in St. Petersburg, and the Museum of Contemporary Art in San Diego. He is represented by Office Baroque in Brussels, Belgium.
In a 2008 article in the magazine Interview, Christopher Bollen described Cerletty as an artist who "could have remained his generation's premier portrait artist." Since then his practice has expanded to include text, patterned abstraction, landscape, and many other genres of painting.
He uses a variety of painting styles, most notably hyper-realistic precision, to bring significance to ordinary and unexpected subjects–from corporate logos, to cinder block walls, to Ikea furniture. In the vein of surrealists like René Magritte, his paintings present the familiar as peculiar. Although Cerletty approaches his images with a tongue-in-cheek humor, there is an underlying sincerity in his attention to detail.