Matricellular protein

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A matricellular protein is a dynamically expressed non-structural protein that is present in the extracellular matrix (ECM).[1][2] Rather than serving as stable structural elements in the ECM, these proteins are rapidly turned over and have regulatory roles. They characteristically contain binding sites for ECM structural proteins and cell surface receptors, and may sequester and modulate activities of specific growth factors.[3][4]

Examples of matricellular proteins include the CCN family of proteins (also known as CCN intercellular signaling protein),[5] fibulins, osteopontin, periostin, SPARC family members, tenascin(s), and thrombospondins. Many of these proteins have important functions in wound healing and tissue repair.

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  1. ^ Bornstein P (August 1995). "Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1". J. Cell Biol. 130 (3): 503–6. PMC 2120533Freely accessible. PMID 7542656. doi:10.1083/jcb.130.3.503. 
  2. ^ Bornstein P, Sage EH (October 2002). "Matricellular proteins: extracellular modulators of cell function". Curr. Opin. Cell Biol. 14 (5): 608–16. PMID 12231357. doi:10.1016/S0955-0674(02)00361-7. 
  3. ^ Roberts DD, Lau LF (2011). "Chapter 11: Matricellular Proteins". In Mecham RP. The Extracellular Matrix: an Overview (Biology of Extracellular Matrix). Berlin: Springer. ISBN 3-642-16554-0. 
  4. ^ Roberts DD (October 2011). "Emerging functions of matricellular proteins". Cell. Mol. Life Sci. 68 (19): 3133–6. PMC 3556643Freely accessible. PMID 21833584. doi:10.1007/s00018-011-0779-2. 
  5. ^ Jun JI, Lau LF (December 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nat Rev Drug Discov. 10 (12): 945–63. PMID 22129992. doi:10.1038/nrd3599.