Zamparini has business interest in several fields, with Emmezetadepartment stores being the most important one. He entered into football in 1987, after having bought then Serie C2 club Venezia, saving it from a possible bankruptcy. His investments in the football club led Venezia to reach Serie A in a few years. He sold Venezia in 2002 in order to buy then-Serie B club Palermo from AS Roma chairman Franco Sensi with the goal to bring the Sicilian team back to Serie A in a very few years, a goal that was achieved in 2004.
In April 2012 he was suspended one year for involvement in third-party ownership; however, this was shortened to 5 months after appeal. He is also famous for firing managers quite regularly.