Mauro Ferrari

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Mauro Ferrari, PhD
Born (1959-07-07) July 7, 1959 (age 59)
Padova, Italy
NationalityItaly, United States
Alma mater
Known for
Spouse(s)
Paola Ferrari (m. 1995)
Childrenfive
Awards
Scientific career
FieldsNanomedicine
Institutions
Websitewww.houstonmethodist.org/research/our-faculty/labs/ferrari-lab/

Mauro Ferrari (born 1959) is a nanoscientist[1] known[2] for leadership in founding the field of nanomedicine and serving as special expert on nanotechnology for the National Cancer Institute (2003-2005) where he was instrumental in establishing the Alliance for Nanotechnology in Cancer in 2004.[3][4][5][6][7]

Early life and education[edit]

Ferrari was born in Padova, Italy in 1959. He spent his early years in Udine and Florence before attending the University of Padova and earning his Laurea in Mathematics in 1985. He moved to Berkeley, California earn his master's and doctorate in mechanical engineering from the University of California Berkeley.[8] [9][10]

Career[edit]

Ferrari became an associate professor of engineering at Berkeley, then moved to the Ohio State University as professor of bioengineering, internal medicine, and mechanical engineering.[11] He studied medicine at the Ohio State University concurrent with his faculty appointment from 2002-2004.[12] He moved to the MD Anderson Cancer Center and University of Texas Health Science Center at Houston, TX to become the chair of the department of nanomedicine and biomedical engineering, and then in 2010 accepted the position of president and CEO of the Houston Methodist Research Institute in Houston, TX.[13] He was appointed to Chief Commercialization Officer of Houston Methodist in 2018, and retired in 2019.

Research Interests[edit]

Ferrari's research uses nanotechnology, microtechnology, physical sciences, mathematics, biomechanics, and material sciences to develop new technologies for health care applications like drug delivery and cancer therapeutics.[14][15] He leads a physical sciences in oncology center, one of a network of centers sponsored by the National Institutes of Health National Cancer Center. The research of this center focuses on understanding the physical and biomechanical biological barriers that reduce the efficacy of cancer therapeutics.[16] He developed a new drug called iNPG-pDox, composed of silicon nanoparticles loaded with polymeric doxorubicin, that had better results at lower doses in animal models compared to standard doxorubicin chemotherapy for metastatic breast cancer.[17][18]

Published works[edit]

Ferrari has produced more than 350 publications, including seven books and 41 issued patents in the US and Europe.

Books[edit]

  • Ferrari M, Granik VT, Imam A, Nadeau J, editors. Advances in Doublet Mechanics. Lecture Notes in Physics, New Series M: Monographs, vol. m 45. Berlin, Heidelberg, New York: Springer Verlag; 1997. ISBN 978-3-540-49636-6
  • Ferrari M. Micro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications. SPIE, The International Society for Optical Engineering; 1999 Jan. ISBN 9780819423894
  • Lee A, Lee J, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol I: Biological and Biomedical Nanotechnology. Springer. 2006. ISBN 978-0-387-25842-3
  • Ozkan M, Heller M, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol II: Micro/Nanotechnologies for Genomics and Proteomics. Springer. 2006. ISBN 978-0387255644
  • Desai T, Bhatia SN, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol III: Therapeutic Micro/Nanotechnologies. Springer. 2006. ISBN 978-1850758600
  • Bashir R, Werely S, Ferrari M, editors. BioMEMS and Biomedical Nanotechnology. Vol IV: Biomolecular Sensing, Processing, and Analysis. Springer. 2006. ISBN 978-0387255668
  • Cristini V, Ferrari M, Decuzzi P, editors. Nanoparticulate Delivery to Cancerous Lesions: Advances in Mathematical Modeling. Ferrari M, series editor. Fundamental Biomedical Technologies. Vol. 2. Springer. April 2010. ISBN 978-0387290850

Journal articles[edit]

Patents[edit]

  • WO application 201517777, Fine D, Grattoni A, Ferrari M, Liu X, Goodall R, Hosali S, "Therapeutic microdevices and methods of making and using same", published 2015 
  • US patent 8926994, Ferrari M, Serda R, Meraz IM, Gu J, Xia X, Shen H, Sun T, "Mesoporous silicon particles for the presentation of tumor antigens and adjuvant for anti-cancer immunity", published 2015 
  • US patent 8685755, Ferrari M, Tasciotti E, Liu X, Bouamrani A, Hu Y, "Combinational multidomain mesoporous chips and a method for fractionation, stabilization, and storage of biomolecules", published 2014 
  • US patent 8753897, Ferrari M, Cheng MM-C, Cuda G, Gaspari M, Geho D, Liotta L, Petricoin E, Robertson F, Terracciano R, "Nanoporous substrates for the [sic] analytical methods", published 2014 
  • US patent 8920625, Ferrari M, Liu X, Cheng MC, "Electrochemical method of making porous particles using a constant current density", published 2014 
  • US patent 8361508, Decuzzi P, Ferrari M, "Endocytotic Particles", published 2013 
  • US patent 8480637, Ferrari M, Liu X, Grattoni, Fine D, Goodall R, Hosali S, Medema R, Hudson L, "Nanochanneled device and related methods", published 2013 
  • US patent 8563022, Decuzzi P, Ferrari M, "Particles for cell targeting", published 2013 
  • US patent 8568877, Ferrari M, Liu X, Chiappini C, Fakhoury JR, "Porous and non-porous nanostructures", published 2013 
  • US patent 8173115, Ferrari M, Decuzzi P, "Particle compositions with a pre-selected cell internalization mode", published 2012 
  • US patent 7993271, Liu J, Ferrari M, Rokhlin SI, Sedmark DD, "System and method for screening tissue", published 2011 
  • US patent 6355270, Ferrari M, Dehlinger PJ, Martin FJ, Grove CF, Friend DR, "Particles for oral delivery of peptides and proteins", published 2002 
  • US patent 6405066, Essenpreis M, Desai TA, Ferrari M, Hansford DJ, "Implantable analyte sensor", published 2002 
  • US patent 6015559, Keller CG, Ferrari M, "High vertical aspect ratio thin film structures", published 2000 
  • US patent 6044981, Chu WH, Ferrari M, "Microfabricated filter with specially constructed channel walls and containment well, and capsule constructed with such filters [II]", published 2000 
  • US patent 6107102, Ferrari M, "Therapeutic microdevices and methods of making and using same", published 2000 
  • US patent 5985164, Chu WH, Ferrari M, "Method for forming a filter", published 1999 
  • US patent 5893974, Keller CG, Ferrari M, "Microfabricated capsules for immunological isolation of cell transplants", published 1999 
  • US patent 5938923, Tu J, Ferrari M, "Microfabricated filter and capsule using a substrate sandwich", published 1999 
  • US patent 5948255, Keller CG, Ferrari M, "Microfabricated particle thin film filter and method of making it", published 1999 
  • US patent 5985328, Chu WH, Ferrari M, "Micromachined porous membranes with bulk support [II]", published 1999 
  • US patent 5770076, Chu WH, Ferrari M, "Micromachined capsules having porous membranes and bulk supports [I]", published 1998 
  • US patent 5798042, Chu WH, Ferrari M, "Microfabricated filter with specially constructed channel walls and containment well, and capsule constructed with such filters [I]", published 1998 

Honors, decorations, awards and distinctions[edit]

Personal life[edit]

Ferrari met and married Marialuisa while they were both students at the University of Padova, and they moved to Berkeley, California. While he was faculty at the University of California Berkeley, Marialuisa lost a battle with cancer.[24] [25][26] Ferrari married Paola (Del Zotto) Ferrari from Udine, Italy in 1995. He has five children, including two sets of twins.[27] [28]

References[edit]

  1. ^ "Mauro Ferrari". Scholar.google.com. Retrieved June 13, 2017.
  2. ^ "Nano-balls filled with poison wipe out metastatic cancer in mice". Sciencemag.com. March 14, 2016. Retrieved 2017-07-23.
  3. ^ "National Cancer Institute Alliance for Nanotechnology". National Institutes of Health. Retrieved 2 March 2017.
  4. ^ Kulkarni, Rajan (2007). "Nano-Bio-Genesis: tracing the rise of nanotechnology and nanobiotechnology as 'big science'". Journal of Biomedical Discovery and Collaboration. 2:3: 3. doi:10.1186/1747-5333-2-3.
  5. ^ Burgess, Rob. 2012. "Understanding Nanomedicine: An Introductory Textbook". Singapore: Pan Stanford. ISBN 9789814316385
  6. ^ Jones, Dan (2007). "Cancer nanotechnology: small, but heading for the big time". Nature Reviews Drug Discovery. 6 (3): 174–175. doi:10.1038/nrd2285. Retrieved March 2, 2017.
  7. ^ "Nanotechnology". Nature Reviews Drug Discovery. 8 (11): 911. 2009. doi:10.1038/nrd3029. Retrieved March 2, 2017.
  8. ^ Ferrari, Mauro (March 23, 2011). "Transcript: The Marvels of Nanotechnology" (PDF). Columbia University Crossroads Culture Center. Retrieved February 28, 2017.
  9. ^ Ferrari, Mauro (March 23, 2011). "Event: The Marvels of Nanotechnology". Columbia University Crossroads Culture Center. Retrieved February 28, 2017.
  10. ^ Chien, Shanley (2017). "TMC Spotlight: Mauro Ferrari, Ph.D." TMC News. 4:2: 7–8. Retrieved March 2, 2017.
  11. ^ "Mauro Ferrari, Ph.D Joins The Methodist Hospital Research Institute as President and CEO". Newswise. August 12, 2010. Retrieved June 16, 2017.
  12. ^ Ferrari M (2009). "Straight talk with Mauro Ferrari". Nature Medicine. 15 (7): 716–7. doi:10.1038/nm0709-716. PMID 19584847.
  13. ^ "Mauro Ferrari, Ph.D Joins The Methodist Hospital Research Institute as President and CEO". Newswise. August 12, 2010. Retrieved June 16, 2017.
  14. ^ "Mauro Ferrari". Scholar.google.com. Retrieved June 13, 2017.
  15. ^ "Mauro Ferrari". Houstonmethodist.org. Retrieved June 15, 2017.
  16. ^ "PS-OC Center". Cancer.gov. Retrieved June 15, 2017.
  17. ^ Xu R, et al. (2016). "An injectable nanoparticle generator enhances delivery of cancer therapeutics". Nat Biotechnol. 34 (4): 414–8. doi:10.1038/nbt.3506. PMC 5070674.
  18. ^ "Nano-balls filled with poison wipe out metastatic cancer in mice". Sciencemag.org. March 14, 2016. Retrieved 2017-07-23.
  19. ^ "Three BME Faculty Elected to American Institute for Medical and Biological Engineering (AIMBE) Fellows". The University of Texas. Retrieved June 13, 2017.
  20. ^ "Mauro Ferrari". American Association for the Advancement of Science. Retrieved June 13, 2017.
  21. ^ "CRS Founders Award Recipients". Controlledreleasesociety.org. Retrieved June 16, 2017.
  22. ^ "The Blaise Pascal medals 2012 Recipients". European Academy of Sciences. Retrieved June 16, 2017.
  23. ^ "TNanomedicine pioneer Mauro Ferrari at ETH Zurich". ETH Zurich. Retrieved June 16, 2017.
  24. ^ Ferrari, Mauro (March 23, 2011). "Transcript: The Marvels of Nanotechnology" (PDF). Columbia University Crossroads Culture Center. Retrieved February 28, 2017.
  25. ^ Ferrari, Mauro (March 23, 2011). "Event: The Marvels of Nanotechnology". Columbia University Crossroads Culture Center. Retrieved February 28, 2017.
  26. ^ Chien, Shanley (2017). "TMC Spotlight: Mauro Ferrari, Ph.D." TMC News. 4:2: 7–8. Retrieved March 2, 2017.
  27. ^ Ferrari, Mauro (March 23, 2011). "Transcript: The Marvels of Nanotechnology" (PDF). Columbia University Crossroads Culture Center. Retrieved February 28, 2017.
  28. ^ Ferrari, Mauro (March 23, 2011). "Event: The Marvels of Nanotechnology". Columbia University Crossroads Culture Center. Retrieved February 28, 2017.