Mavoglurant is under development by Novartis and is currently in Phase II and Phase III clinical trials. Phase IIb/III dose finding and evaluation trials for fragile X-syndrome have been discontinued by the end of 2014. Otherwise, it would have been the first drug to treat the underlying disorder instead of the symptoms of fragile X syndrome.
Mavoglurant is also in Phase II clinical trials for Levodopa-induced dyskinesia.
In 2007, Norvartis had conducted a clinical study to assess its ability of reducing cigarette smoking, but no results had been published up till now.
Currently Novartis is conducting a clinical trial with this drug on obsessive compulsive disorder.
Novartis discontinued development of mavoglurant for fragile X syndrome in April 2014 following disappointing trial results.
^ abP. Cole (2012). "Mavoglurant". Drugs of the Future37 (1): 7–12. doi:10.1358/dof.2012.37.1.1772147 (inactive 2015-02-01).
^Levenga, J; Hayashi, S; De Vrij, FM; Koekkoek, SK; Van Der Linde, HC; Nieuwenhuizen, I; Song, C; Buijsen, RA; et al. (2011). "AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome". Neurobiology of disease42 (3): 311–7. doi:10.1016/j.nbd.2011.01.022. PMID21316452.
^Jacquemont, S.; Curie, A.; Des Portes, V.; Torrioli, M. G.; Berry-Kravis, E.; Hagerman, R. J.; Ramos, F. J.; Cornish, K.; et al. (2011). "Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome is Associated with Differential Response to the mGluR5 Antagonist AFQ056". Science Translational Medicine3 (64): 64ra1. doi:10.1126/scitranslmed.3001708. PMID21209411.
^Kumar, R; Hauser, R. A.; Mostillo, J; Dronamraju, N; Graf, A; Merschhemke, M; Kenney, C (Sep 2013). "Mavoglurant (AFQ056) in combination with increased levodopa dosages in Parkinson's disease patients". Int J Neurosci: 1. doi:10.3109/00207454.2013.841685. PMID24007304.