Maximiscin

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Maximiscin
Maximiscin.svg
Names
IUPAC name
Methyl (3S,4S,5S,6R)-6-({3-[(1R,2S,4R,6S)-2-ethenyl-4,6-dimethylcyclohexyl]-4-hydro-oxo-1,2-dihydropyridin-1-yl}oxy)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylate
Identifiers
3D model (JSmol)
ChemSpider
Properties
C23H31NO8
Molar mass 449.50 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Maximiscin is a polyketide-shikimate isolate of Tolypocladium with anticancer activity.[1] The discovery of maximiscin was the result of a citizen scientist crowdsourcing project by the University of Oklahoma.[2] The soil sample which yielded maximiscin was sent by a woman from Salcha, Alaska.[3]

References[edit]

  1. ^ Du, L; Robles, AJ; King, JB; Powell, DR; Miller, AN; Mooberry, SL; Cichewicz, RH (2013). "Maximiscin, a Novel Shikimate-Polyketide-NRPS Hybrid Metabolite Obtained from Tolypocladium Sp. With Potent Antitumor Activities". Planta Medica. 79 (10). doi:10.1055/s-0033-1348528. 
  2. ^ Du, L; Robles, AJ; King, JB; Powell, DR; Miller, AN; Mooberry, SL; Cichewicz, RH (2013). "Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity". Angewandte Chemie International Edition in English. 53 (3): 804–9. PMC 4028707Freely accessible. PMID 24285637. doi:10.1002/anie.201306549. 
  3. ^ Crowdsourcing unearths promising anticancer compound