The settlement of Mazatán was founded in the seventeenth century by the Jesuit Juan Nentuig. Its name comes from the Opata language and means "place of deer". During the nineteenth century Mazatán belonged to the district of Ures. It became a municipality on 10 December 1907. 
The region is part of the valleys of the center of the state. The average annual temperature is 21.7°C and the average annual rainfall is 508.8 mm. 
The region is crossed by the Rio Mazatán, which has an extension of 160 kilometers and flows into the Punta de Agua reservoir near Guaymas.
Agriculture and cattle raising are the main economic activities.
Corn and beans are raised for subsistence while grasses (sorghum, alfalfa, rye grass) are grown for cattle fodder.
The town church and the dance of the fans in August.