McFarlane Strait is a strait lying between Greenwich Island and Livingston Island, in the South Shetland Islands off Antarctica. It is 24 kilometres (13 nmi) long and 3 kilometres (1.6 nmi) wide. The name appears on an 1822 chart by Captain George Powell, a British sealer, and is now well established in international usage.
The strait is centred at (Coordinates: ), and entered between Williams Point and Duff Point to the northwest and between Renier Point and Ephraim Bluff to the southeast (British mapping in 1822 and 1968, Chilean mapping in 1971, Argentine mapping in 1980, Spanish mapping in 1991, and Bulgarian mapping in 2005 and 2009).
- Chart of South Shetland including Coronation Island, &c. from the exploration of the sloop Dove in the years 1821 and 1822 by George Powell Commander of the same. Scale ca. 1:200000. London: Laurie, 1822.
- L.L. Ivanov et al., Antarctica: Livingston Island and Greenwich Island, South Shetland Islands (from English Strait to Morton Strait, with illustrations and ice-cover distribution), 1:100000 scale topographic map, Antarctic Place-names Commission of Bulgaria, Sofia, 2005
- L.L. Ivanov. Antarctica: Livingston Island and Greenwich, Robert, Snow and Smith Islands. Scale 1:120000 topographic map. Troyan: Manfred Wörner Foundation, 2009. ISBN 978-954-92032-6-4
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