Mean platelet volume

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Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems.[1]

MPV is higher when there is destruction of platelets. This may be seen in inflammatory bowel disease,[2] immune thrombocytopenic purpura (ITP), myeloproliferative diseases and Bernard-Soulier syndrome. It may also be related to pre-eclampsia, and recovery from, transient hypoplasia.[3]

Abnormally low MPV values correlate with thrombocytopenia when it is due to impaired production as in aplastic anemia. In addition, low MPV can correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as Wiskott-Aldrich Syndrome (WAS),[4] caused by a genetic mutation of the WAS gene.

A typical range of platelet volumes is 9.7–12.8 fL (femtolitre), equivalent to spheres 2.65 to 2.9 µm in diameter. Normal range is given as 7.5-11.5 fL.[5]

External links[edit]

  • [3] Immune Deficiency Foundation entry for Wiskott-Aldrich Syndrome
  • MPV Definition
  • [4] Thrombocytopenia
  • [5] MPV
  • [6] Article related to MPV
  • Bessman, JD; Gilmer, PR; Gardner, FH. "Use of mean platelet volume improves detection of platelet disorders". Blood Cells. 11: 127–35. PMID 4074887. 
  • [7] Wisegeekcom: What is Mean Platelet Volume
  • [8] MPV
  1. ^ [1], Lab Tests Online.
  2. ^ Liu, S; Ren, J; Han, G; Wang, G; Gu, G; Xia, Q; Li, J (Oct 12, 2012). "Mean platelet volume: a controversial marker of disease activity in Crohn's disease". European Journal of Medical Research. 17: 27. doi:10.1186/2047-783x-17-27. PMC 3519557Freely accessible. PMID 23058104. 
  3. ^ [2], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..
  4. ^ Immune Deficiency Foundation  Missing or empty |title= (help)
  5. ^  Missing or empty |title= (help)