Mebolazine
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| Trade names | Dostalon, Roxilon |
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| Synonyms | Dimethazine, Dymethazine; Dimethasterone azine; Di(methasterone) azine; 2α,17α-Dimethyl-5α-androstan-17β-ol-3-one azine |
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| Formula | C42H68N2O2 |
| Molar mass | 633.02 g·mol−1 |
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Mebolazine (INN; brand names Dostalon and Roxilon; also known as dimethazine, dymethazine, di(methasterone) azine, or 2α,17α-dimethyl-5α-androstan-17β-ol-3-one azine) is a synthetic, orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of dihydrotestosterone (DHT) that is no longer marketed.[1][2] It has a unique and unusual chemical structure, being a dimer of methasterone linked at the 3-position of the A-ring by an azine group, and reportedly acts as a prodrug of methasterone.[3]
Since 2008, mebolazine has been used illegally as an ingredient is some dietary supplements,[4] including vitamin B supplements, and in the United States the Food and Drug Administration has taken legal action against such manufacturers.[5][6]
See also[edit]
References[edit]
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 756–. ISBN 978-1-4757-2085-3.
- ^ Geldof L, Tudela E, Lootens L, van Lysebeth J, Meuleman P, Leroux-Roels G, van Eenoo P, Deventer K (2016). "In vitro and in vivo metabolism studies of dimethazine". Biomed. Chromatogr. 30 (8): 1202–9. PMID 26663462. doi:10.1002/bmc.3668.
- ^ Clemens, Roger; Pressman, Peter (2015). "Nutritional and Dietary Supplements: Code or Concern". Preventive Nutrition: 47–62. ISBN 978-3-319-22430-5. doi:10.1007/978-3-319-22431-2_3.
- ^ Rahnema, C. D.; Crosnoe, L. E.; Kim, E. D. (2015). "Designer steroids - over-the-counter supplements and their androgenic component: Review of an increasing problem". Andrology. 3 (2): 150. PMID 25684733. doi:10.1111/andr.307.
- ^ See, for example: "FDA Warns Consumers About Health Risks With Healthy Life Chemistry Dietary Supplement". Food and Drug Administration.
- ^ "Criminal Investigations (2011) Dietary Supplements Manufacturer Sentenced". Department of Justice.
